Detailed information of TA system TA041316

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4659140..4659742
• Replicon: chromosome
• Accession: NZ_AP025836
• Organism: Enterobacter hormaechei strain FUJ80199

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A155DUZ6
• Locus tag: NMC34_RS22365
• Protein ID: WP_022649837.1
• Coordinates: 4659431..4659742 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: NMC34_RS22360
• Protein ID: WP_022649836.1
• Coordinates: 4659140..4659430 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NMC34_RS22345 (FJMB80199_43780)	4656638..4657540	+	903	WP_003861960.1	formate dehydrogenase subunit beta	-
NMC34_RS22350 (FJMB80199_43790)	4657537..4658172	+	636	WP_006808711.1	formate dehydrogenase cytochrome b556 subunit	-
NMC34_RS22355 (FJMB80199_43800)	4658169..4659098	+	930	WP_022649835.1	formate dehydrogenase accessory protein FdhE	-
NMC34_RS22360 (FJMB80199_43810)	4659140..4659430	-	291	WP_022649836.1	NadS family protein	Antitoxin
NMC34_RS22365 (FJMB80199_43820)	4659431..4659742	-	312	WP_022649837.1	hypothetical protein	Toxin
NMC34_RS22370 (FJMB80199_43830)	4659891..4660832	-	942	WP_022649838.1	fatty acid biosynthesis protein FabY	-
NMC34_RS22375 (FJMB80199_43840)	4660877..4661314	-	438	WP_022649839.1	D-aminoacyl-tRNA deacylase	-
NMC34_RS22380 (FJMB80199_43850)	4661311..4662192	-	882	WP_022649840.1	virulence factor BrkB family protein	-
NMC34_RS22385 (FJMB80199_43860)	4662186..4662785	-	600	WP_022649841.1	glucose-1-phosphatase	-
NMC34_RS22390 (FJMB80199_43870)	4662904..4663704	-	801	WP_022649842.1	DeoR/GlpR family DNA-binding transcription regulator	-
NMC34_RS22395 (FJMB80199_43880)	4663739..4664635	-	897	WP_022649843.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12148.13 Da
• Isoelectric Point: 9.4455

>T41316 WP_022649837.1 NZ_AP025836:c4659742-4659431 [Enterobacter hormaechei]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPDYGDLIQNTGGLRKIRWLAGGKGKRSGVRVIYFHRTRECEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Nucleotide

• Length: 312 bp

>T41316 NZ_AP025836:c4659742-4659431 [Enterobacter hormaechei]
ATGCTATTCATTGAAACGGATATTTTTACAGAAGACGTCAAAACGTTACTGGATGACGACGAATATCATAGGTTCCAAAT
ATTCCTGGCAACGCAACCGGATTACGGCGATCTGATCCAGAATACGGGAGGCTTGCGAAAGATTCGCTGGCTTGCTGGCG
GTAAGGGAAAGCGTAGTGGAGTCAGAGTTATCTATTTTCACCGTACGCGTGAGTGTGAAATCAGGTTGCTGCTCATCTAT
CGCAAAGGGATCAAAGATGACCTCTCCGCGGGTGAAAAAGCCATACTGAAAAAGATGATTGAGAGGTGGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10699.21 Da
• Isoelectric Point: 10.5888

>AT41316 WP_022649836.1 NZ_AP025836:c4659430-4659140 [Enterobacter hormaechei]
MDKALFERLTQSIAQINEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALTQ

Nucleotide

• Length: 291 bp

>AT41316 NZ_AP025836:c4659430-4659140 [Enterobacter hormaechei]
ATGGATAAGGCGCTGTTTGAGCGATTAACCCAAAGCATTGCGCAAATCAACGAAATTGCCGAGGGCCAACGAGAGCCGTC
GCGTACGTTTCAAATTGATGCGATGAAAATAAAAGAAATTCGTCAGGCGTCCGGGTTGTCGCAGAGTAAATTCGCGAACT
TAATCTCAGTTAGCGTTGATACGTTGCGTAACTGGGAACAAGGCAGACGCTCACCTACAGGCCCCGCTAAAGCGCTATTG
CGCGCCATTGCTAACGACCCTCAACATGTCATCCCAGCCCTAACGCAGTAA

Structures

Toxin

• AlphaFold DB: A0A155DUZ6