Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 82527..82780 | Replicon | plasmid pla1 |
| Accession | NZ_AP025752 | ||
| Organism | Escherichia sp. HH154_1D strain HH-P049 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | QUE53_RS26755 | Protein ID | WP_001312851.1 |
| Coordinates | 82527..82676 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 82724..82780 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE53_RS26720 (78248) | 78248..78673 | + | 426 | Protein_93 | transposase | - |
| QUE53_RS26725 (78789) | 78789..79040 | + | 252 | WP_135276003.1 | hypothetical protein | - |
| QUE53_RS26730 (79487) | 79487..79804 | + | 318 | Protein_95 | transposase | - |
| QUE53_RS26735 (79938) | 79938..80124 | - | 187 | Protein_96 | hypothetical protein | - |
| QUE53_RS26740 (80827) | 80827..81684 | - | 858 | WP_000829162.1 | incFII family plasmid replication initiator RepA | - |
| QUE53_RS26745 (81677) | 81677..81751 | - | 75 | WP_001364037.1 | RepA leader peptide Tap | - |
| QUE53_RS26750 (81995) | 81995..82243 | - | 249 | WP_000083838.1 | replication regulatory protein RepA | - |
| QUE53_RS26755 (82527) | 82527..82676 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (82724) | 82724..82780 | + | 57 | NuclAT_1 | - | Antitoxin |
| - (82724) | 82724..82780 | + | 57 | NuclAT_1 | - | Antitoxin |
| - (82724) | 82724..82780 | + | 57 | NuclAT_1 | - | Antitoxin |
| - (82724) | 82724..82780 | + | 57 | NuclAT_1 | - | Antitoxin |
| QUE53_RS26760 (82932) | 82932..83396 | - | 465 | WP_000455478.1 | hypothetical protein | - |
| QUE53_RS26765 (83551) | 83551..84141 | - | 591 | WP_000766788.1 | DUF2726 domain-containing protein | - |
| QUE53_RS26770 (84179) | 84179..84388 | - | 210 | WP_001355319.1 | hemolysin expression modulator Hha | - |
| QUE53_RS26775 (84716) | 84716..84928 | - | 213 | WP_001364091.1 | hypothetical protein | - |
| QUE53_RS26780 (85063) | 85063..85623 | - | 561 | WP_000139355.1 | fertility inhibition protein FinO | - |
| QUE53_RS26785 (85678) | 85678..86415 | - | 738 | WP_000429592.1 | conjugal transfer pilus acetylase TraX | - |
| QUE53_RS26790 (86437) | 86437..86868 | - | 432 | WP_000447372.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | hlyD / hlyD / hlyD / hlyB / hlyB / hlyA / hlyA / hlyC / estIa / faeJ / faeI / faeH / faeF / faeE / faeD / faeC / espP | 1..220055 | 220055 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T40810 WP_001312851.1 NZ_AP025752:c82676-82527 [Escherichia sp. HH154_1D]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T40810 NZ_AP025752:c82676-82527 [Escherichia sp. HH154_1D]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCTGTGTGCGCTACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTTTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCTGTGTGCGCTACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTTTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 57 bp
>AT40810 NZ_AP025752:82724-82780 [Escherichia sp. HH154_1D]
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATCTCT
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATCTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
