Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1724543..1724914 | Replicon | chromosome |
| Accession | NZ_AP025751 | ||
| Organism | Escherichia sp. HH154_1D strain HH-P049 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A839BBC2 |
| Locus tag | QUE53_RS08550 | Protein ID | WP_021500490.1 |
| Coordinates | 1724720..1724914 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1724543..1724721 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE53_RS08520 (1720294) | 1720294..1720467 | + | 174 | WP_001296046.1 | protein YnaL | - |
| QUE53_RS08525 (1720498) | 1720498..1721871 | + | 1374 | WP_000123713.1 | ATP-dependent RNA helicase DbpA | - |
| QUE53_RS08530 (1722000) | 1722000..1722935 | - | 936 | WP_001157387.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| QUE53_RS08535 (1722987) | 1722987..1724222 | - | 1236 | WP_000040840.1 | site-specific integrase | - |
| QUE53_RS08540 (1724224) | 1724224..1724439 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1724543) | 1724543..1724721 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1724543) | 1724543..1724721 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1724543) | 1724543..1724721 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1724543) | 1724543..1724721 | + | 179 | NuclAT_0 | - | Antitoxin |
| QUE53_RS08545 (1724539) | 1724539..1724727 | - | 189 | WP_001356607.1 | DUF1187 family protein | - |
| QUE53_RS08550 (1724720) | 1724720..1724914 | - | 195 | WP_021500490.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| QUE53_RS08555 (1724978) | 1724978..1726066 | - | 1089 | WP_001355266.1 | recombinase RecT | - |
| QUE53_RS08560 (1726081) | 1726081..1729227 | - | 3147 | WP_000105093.1 | exodeoxyribonuclease VIII | - |
| QUE53_RS08565 (1729329) | 1729329..1729604 | - | 276 | WP_001355267.1 | hypothetical protein | - |
| QUE53_RS08570 (1729679) | 1729679..1729855 | - | 177 | WP_000258918.1 | YdaE family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | paa | 1715727..1772046 | 56319 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7046.98 Da Isoelectric Point: 9.2886
>T40789 WP_021500490.1 NZ_AP025751:c1724914-1724720 [Escherichia sp. HH154_1D]
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T40789 NZ_AP025751:c1724914-1724720 [Escherichia sp. HH154_1D]
ATGCGGTATGAAAAAGTCAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTTAAAGCTATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
ATGCGGTATGAAAAAGTCAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTTAAAGCTATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
Antitoxin
Download Length: 179 bp
>AT40789 NZ_AP025751:1724543-1724721 [Escherichia sp. HH154_1D]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
