Detailed information of TA system TA040767

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 5292511..5292923
• Replicon: chromosome
• Accession: NZ_AP025747
• Organism: Escherichia sp. HH091_1A strain HH-P024

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A8D9PK47
• Locus tag: QUF14_RS26150
• Protein ID: WP_000132619.1
• Coordinates: 5292511..5292852 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	5292847..5292923 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUF14_RS26130 (5288521)	5288521..5289933	-	1413	WP_000199312.1	PLP-dependent aminotransferase family protein	-
QUF14_RS26135 (5290110)	5290110..5290274	+	165	WP_000394281.1	DUF1127 domain-containing protein	-
QUF14_RS26140 (5290371)	5290371..5291253	+	883	Protein_5097	DUF262 domain-containing protein	-
QUF14_RS26145 (5291301)	5291301..5292464	+	1164	WP_138983873.1	DUF1524 domain-containing protein	-
QUF14_RS26150 (5292511)	5292511..5292852	-	342	WP_000132619.1	endoribonuclease SymE	Toxin
- (5292847)	5292847..5292923	+	77	NuclAT_23	-	Antitoxin
- (5292847)	5292847..5292923	+	77	NuclAT_23	-	Antitoxin
- (5292847)	5292847..5292923	+	77	NuclAT_23	-	Antitoxin
- (5292847)	5292847..5292923	+	77	NuclAT_23	-	Antitoxin
- (5292847)	5292847..5292923	+	77	NuclAT_24	-	Antitoxin
- (5292847)	5292847..5292923	+	77	NuclAT_24	-	Antitoxin
- (5292847)	5292847..5292923	+	77	NuclAT_24	-	Antitoxin
- (5292847)	5292847..5292923	+	77	NuclAT_24	-	Antitoxin
QUF14_RS26155 (5293073)	5293073..5294824	-	1752	WP_000110091.1	restriction endonuclease subunit S	-
QUF14_RS26160 (5294824)	5294824..5296293	-	1470	WP_001387312.1	type I restriction-modification system subunit M	-
QUF14_RS26165 (5296360)	5296360..5297229	-	870	Protein_5102	type I restriction-modification enzyme R subunit C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12322.13 Da
• Isoelectric Point: 7.8219

>T40767 WP_000132619.1 NZ_AP025747:c5292852-5292511 [Escherichia sp. HH091_1A]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAPEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T40767 NZ_AP025747:c5292852-5292511 [Escherichia sp. HH091_1A]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCCCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAACTGTCAGCGCGTAAACAGAAGCAGGTGCAGGAGTTTATTGGGGTGATTGC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT40767 NZ_AP025747:5292847-5292923 [Escherichia sp. HH091_1A]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin