Detailed information of TA system TA040748

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1679033..1679404
• Replicon: chromosome
• Accession: NZ_AP025747
• Organism: Escherichia sp. HH091_1A strain HH-P024

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: -
• Locus tag: QUF14_RS08295
• Protein ID: WP_265751826.1
• Coordinates: 1679210..1679404 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1679033..1679211 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUF14_RS08265 (1674784)	1674784..1674957	+	174	WP_038813008.1	protein YnaL	-
QUF14_RS08270 (1674988)	1674988..1676361	+	1374	WP_100733964.1	ATP-dependent RNA helicase DbpA	-
QUF14_RS08275 (1676490)	1676490..1677425	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
QUF14_RS08280 (1677477)	1677477..1678712	-	1236	WP_000040852.1	site-specific integrase	-
QUF14_RS08285 (1678714)	1678714..1678929	-	216	WP_000079604.1	excisionase XisR	-
- (1679033)	1679033..1679211	+	179	NuclAT_0	-	Antitoxin
- (1679033)	1679033..1679211	+	179	NuclAT_0	-	Antitoxin
- (1679033)	1679033..1679211	+	179	NuclAT_0	-	Antitoxin
- (1679033)	1679033..1679211	+	179	NuclAT_0	-	Antitoxin
QUF14_RS08290 (1679008)	1679008..1679217	-	210	WP_000276809.1	double-strand break reduction protein RcbA	-
QUF14_RS08295 (1679210)	1679210..1679404	-	195	WP_265751826.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
QUF14_RS08300 (1679461)	1679461..1680270	-	810	WP_061359309.1	recombination protein RecT	-
QUF14_RS08305 (1680263)	1680263..1682914	-	2652	WP_286333499.1	exodeoxyribonuclease VIII	-
QUF14_RS08310 (1683016)	1683016..1683291	-	276	WP_032218014.1	hypothetical protein	-
QUF14_RS08315 (1683366)	1683366..1683542	-	177	WP_032218016.1	YdaE family protein	-
QUF14_RS08320 (1683536)	1683536..1683757	-	222	WP_000560226.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1677477..1763699	86222

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7008.85 Da
• Isoelectric Point: 8.9538

>T40748 WP_265751826.1 NZ_AP025747:c1679404-1679210 [Escherichia sp. HH091_1A]
MRYDNVKSCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T40748 NZ_AP025747:c1679404-1679210 [Escherichia sp. HH091_1A]
ATGAGATATGACAATGTTAAATCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT40748 NZ_AP025747:1679033-1679211 [Escherichia sp. HH091_1A]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Antitoxin