Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1760515..1760886 | Replicon | chromosome |
| Accession | NZ_AP025741 | ||
| Organism | Escherichia sp. 10290 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A839BBC2 |
| Locus tag | QUE74_RS08820 | Protein ID | WP_021500490.1 |
| Coordinates | 1760692..1760886 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1760515..1760693 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE74_RS08790 (1756266) | 1756266..1756439 | + | 174 | WP_001296046.1 | protein YnaL | - |
| QUE74_RS08795 (1756470) | 1756470..1757843 | + | 1374 | WP_000123713.1 | ATP-dependent RNA helicase DbpA | - |
| QUE74_RS08800 (1757972) | 1757972..1758907 | - | 936 | WP_001157387.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| QUE74_RS08805 (1758959) | 1758959..1760194 | - | 1236 | WP_000040840.1 | site-specific integrase | - |
| QUE74_RS08810 (1760196) | 1760196..1760411 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1760515) | 1760515..1760693 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1760515) | 1760515..1760693 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1760515) | 1760515..1760693 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1760515) | 1760515..1760693 | + | 179 | NuclAT_0 | - | Antitoxin |
| QUE74_RS08815 (1760511) | 1760511..1760699 | - | 189 | WP_001356607.1 | DUF1187 family protein | - |
| QUE74_RS08820 (1760692) | 1760692..1760886 | - | 195 | WP_021500490.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| QUE74_RS08825 (1760950) | 1760950..1762038 | - | 1089 | WP_001355266.1 | recombinase RecT | - |
| QUE74_RS08830 (1762053) | 1762053..1765199 | - | 3147 | WP_000105093.1 | exodeoxyribonuclease VIII | - |
| QUE74_RS08835 (1765301) | 1765301..1765576 | - | 276 | WP_001355267.1 | hypothetical protein | - |
| QUE74_RS08840 (1765651) | 1765651..1765827 | - | 177 | WP_000258918.1 | YdaE family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | paa | 1751699..1844455 | 92756 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7046.98 Da Isoelectric Point: 9.2886
>T40705 WP_021500490.1 NZ_AP025741:c1760886-1760692 [Escherichia sp. 10290]
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T40705 NZ_AP025741:c1760886-1760692 [Escherichia sp. 10290]
ATGCGGTATGAAAAAGTCAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTTAAAGCTATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
ATGCGGTATGAAAAAGTCAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTTAAAGCTATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
Antitoxin
Download Length: 179 bp
>AT40705 NZ_AP025741:1760515-1760693 [Escherichia sp. 10290]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
