Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1989003..1989505 Replicon chromosome
Accession NZ_AP025730
Organism Sphaerotilus sp. FB-5

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag NGK70_RS08745 Protein ID WP_251972863.1
Coordinates 1989251..1989505 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag NGK70_RS08740 Protein ID WP_251972862.1
Coordinates 1989003..1989254 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK70_RS08715 1985215..1985376 + 162 Protein_1722 Glu/Leu/Phe/Val dehydrogenase -
NGK70_RS08720 (CATMQ487_17270) 1985425..1987182 - 1758 WP_251972858.1 enoyl-CoA hydratase-related protein -
NGK70_RS08725 (CATMQ487_17280) 1987199..1987609 - 411 WP_251972859.1 PIN domain-containing protein -
NGK70_RS08730 (CATMQ487_17290) 1987606..1987812 - 207 WP_251972860.1 type II toxin-antitoxin system VapB family antitoxin -
NGK70_RS08735 (CATMQ487_17300) 1987874..1988935 - 1062 WP_251972861.1 hydrogenase expression/formation protein HypE -
NGK70_RS08740 (CATMQ487_17310) 1989003..1989254 + 252 WP_251972862.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NGK70_RS08745 (CATMQ487_17320) 1989251..1989505 + 255 WP_251972863.1 Txe/YoeB family addiction module toxin Toxin
NGK70_RS08750 (CATMQ487_17330) 1989580..1990860 - 1281 WP_251972864.1 hydrogenase formation protein HypD -
NGK70_RS08755 (CATMQ487_17340) 1990857..1991105 - 249 WP_251972865.1 HypC/HybG/HupF family hydrogenase formation chaperone -
NGK70_RS08760 (CATMQ487_17350) 1991129..1992739 - 1611 WP_251972866.1 Sua5/YciO/YrdC/YwlC family protein -
NGK70_RS08765 (CATMQ487_17360) 1992803..1993552 - 750 WP_251972867.1 acylphosphatase -
NGK70_RS08770 (CATMQ487_17370) 1993573..1994472 - 900 WP_251973721.1 hydrogenase nickel incorporation protein HypB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10222.79 Da        Isoelectric Point: 9.3752

>T40675 WP_251972863.1 NZ_AP025730:1989251-1989505 [Sphaerotilus sp. FB-5]
MKLVFADAAWEDYLYWQKQDRKMVERINKLIRETQREPFEGVGKPEPLKHALAGFWSRRITEEHRMVYRVEGDALLIAQL
RYHY

Download         Length: 255 bp

>T40675 NZ_AP025730:1989251-1989505 [Sphaerotilus sp. FB-5]
ATGAAGCTGGTCTTTGCGGACGCCGCATGGGAGGACTACCTCTATTGGCAGAAGCAGGACCGCAAGATGGTGGAGCGCAT
CAACAAGCTGATCCGCGAAACCCAGCGCGAGCCCTTTGAGGGCGTCGGCAAACCCGAGCCGCTGAAGCACGCGCTGGCCG
GCTTCTGGTCACGCCGCATCACCGAAGAGCACCGCATGGTCTACCGGGTCGAGGGCGACGCTTTGCTGATTGCGCAGTTG
CGGTATCACTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9134.26 Da        Isoelectric Point: 4.4796

>AT40675 WP_251972862.1 NZ_AP025730:1989003-1989254 [Sphaerotilus sp. FB-5]
MDAISYSAARANLASTMDRVCNDHEPLIVTRNGQPSVVMLSLEDYQALEETAYLLRSPANARRLLSAVQQLSAGQGQERE
LVE

Download         Length: 252 bp

>AT40675 NZ_AP025730:1989003-1989254 [Sphaerotilus sp. FB-5]
TTGGATGCCATTTCCTACTCGGCCGCGCGCGCCAACCTGGCCAGCACCATGGACCGCGTGTGCAACGACCATGAGCCGCT
GATCGTCACCCGCAACGGCCAGCCCTCGGTGGTGATGCTGTCGCTGGAGGACTACCAGGCGCTGGAGGAGACGGCCTACC
TGCTGCGCAGCCCCGCCAACGCCCGGCGGCTGCTCTCGGCCGTGCAACAGCTCTCGGCCGGCCAGGGCCAGGAGCGGGAG
CTGGTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References