Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2593229..2593752 Replicon chromosome
Accession NZ_AP025693
Organism Staphylococcus aureus strain JICS127

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag M2038_RS13050 Protein ID WP_000074048.1
Coordinates 2593229..2593495 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag M2038_RS13055 Protein ID WP_000587616.1
Coordinates 2593495..2593752 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2038_RS13030 (2588536) 2588536..2589723 - 1188 WP_000026194.1 MFS transporter -
M2038_RS13035 (2590119) 2590119..2590895 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
M2038_RS13040 (2590888) 2590888..2591550 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
M2038_RS13045 (2591798) 2591798..2592874 - 1077 WP_001076671.1 M42 family metallopeptidase -
M2038_RS13050 (2593229) 2593229..2593495 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
M2038_RS13055 (2593495) 2593495..2593752 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M2038_RS13060 (2594110) 2594110..2594565 + 456 WP_000732082.1 DUF1307 domain-containing protein -
M2038_RS13065 (2594733) 2594733..2596310 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
M2038_RS13070 (2596505) 2596505..2597254 + 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
M2038_RS13075 (2597478) 2597478..2598671 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T40668 WP_000074048.1 NZ_AP025693:c2593495-2593229 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T40668 NZ_AP025693:c2593495-2593229 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT40668 WP_000587616.1 NZ_AP025693:c2593752-2593495 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT40668 NZ_AP025693:c2593752-2593495 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References