Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2561729..2561913 Replicon chromosome
Accession NZ_AP025693
Organism Staphylococcus aureus strain JICS127

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag M2038_RS12910 Protein ID WP_000482650.1
Coordinates 2561806..2561913 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2561729..2561789 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2038_RS12895 2557259..2557426 - 168 WP_001790576.1 hypothetical protein -
M2038_RS12900 2557657..2559390 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
M2038_RS12905 2559415..2561178 - 1764 WP_001064838.1 ABC transporter ATP-binding protein -
- 2561729..2561789 + 61 - - Antitoxin
M2038_RS12910 2561806..2561913 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
M2038_RS12915 2562047..2562433 - 387 WP_000779358.1 flippase GtxA -
M2038_RS12920 2562701..2563843 + 1143 WP_001176863.1 glycerate kinase -
M2038_RS12925 2563903..2564562 + 660 WP_000831298.1 membrane protein -
M2038_RS12930 2564744..2565955 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
M2038_RS12935 2566078..2566551 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T40666 WP_000482650.1 NZ_AP025693:c2561913-2561806 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T40666 NZ_AP025693:c2561913-2561806 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT40666 NZ_AP025693:2561729-2561789 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References