Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2536381..2536898 Replicon chromosome
Accession NZ_AP025693
Organism Staphylococcus aureus strain JICS127

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag M2038_RS12775 Protein ID WP_000113262.1
Coordinates 2536381..2536647 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag M2038_RS12780 Protein ID WP_000584502.1
Coordinates 2536647..2536898 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2038_RS12745 (2531807) 2531807..2532343 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
M2038_RS12750 (2532576) 2532576..2533400 - 825 WP_000572040.1 formate/nitrite transporter family protein -
M2038_RS12755 (2533617) 2533617..2533799 - 183 WP_000230294.1 hypothetical protein -
M2038_RS12760 (2533883) 2533883..2534350 - 468 WP_000153344.1 SRPBCC domain-containing protein -
M2038_RS12765 (2534536) 2534536..2536086 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
M2038_RS12770 (2536275) 2536275..2536346 - 72 Protein_2477 hypothetical protein -
M2038_RS12775 (2536381) 2536381..2536647 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
M2038_RS12780 (2536647) 2536647..2536898 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M2038_RS12785 (2537063) 2537063..2537164 - 102 WP_001791744.1 hypothetical protein -
M2038_RS12790 (2537171) 2537171..2537770 - 600 WP_000162813.1 DsbA family protein -
M2038_RS12795 (2537789) 2537789..2538148 - 360 WP_000819847.1 DUF4467 domain-containing protein -
M2038_RS12800 (2538403) 2538403..2539653 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
M2038_RS12805 (2539750) 2539750..2540481 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
M2038_RS12810 (2540478) 2540478..2541197 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T40665 WP_000113262.1 NZ_AP025693:c2536647-2536381 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T40665 NZ_AP025693:c2536647-2536381 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT40665 WP_000584502.1 NZ_AP025693:c2536898-2536647 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT40665 NZ_AP025693:c2536898-2536647 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References