Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2270116..2270333 Replicon chromosome
Accession NZ_AP025693
Organism Staphylococcus aureus strain JICS127

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag M2038_RS11385 Protein ID WP_001802298.1
Coordinates 2270229..2270333 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2270116..2270171 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2038_RS11360 2266253..2266918 - 666 WP_001024094.1 SDR family oxidoreductase -
M2038_RS11365 2267070..2267390 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
M2038_RS11370 2267392..2268372 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
M2038_RS11375 2268638..2269729 + 1092 WP_000495671.1 lytic regulatory protein -
- 2270116..2270171 + 56 - - Antitoxin
M2038_RS11385 2270229..2270333 - 105 WP_001802298.1 hypothetical protein Toxin
M2038_RS11390 2270494..2270977 - 484 Protein_2210 recombinase family protein -
M2038_RS11395 2271020..2272156 - 1137 WP_000115564.1 SAP domain-containing protein -
M2038_RS11400 2272445..2272537 + 93 WP_001790138.1 hypothetical protein -
M2038_RS11410 2273242..2274099 - 858 WP_000370924.1 HAD family hydrolase -
M2038_RS11415 2274167..2274949 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T40664 WP_001802298.1 NZ_AP025693:c2270333-2270229 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T40664 NZ_AP025693:c2270333-2270229 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT40664 NZ_AP025693:2270116-2270171 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References