Detailed information of TA system TA040658

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2095450..2095749
• Replicon: chromosome
• Accession: NZ_AP025693
• Organism: Staphylococcus aureus strain JICS127

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: M2038_RS10390
• Protein ID: WP_011447039.1
• Coordinates: 2095573..2095749 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2095450..2095505 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2038_RS10350	2090781..2091041	+	261	WP_001791826.1	hypothetical protein	-
M2038_RS10355	2091094..2091444	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
M2038_RS10360	2092129..2092578	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
M2038_RS10365	2092673..2093008	-	336	Protein_2010	SH3 domain-containing protein	-
M2038_RS10370	2093658..2094149	-	492	WP_000919350.1	staphylokinase	-
M2038_RS10375	2094340..2095095	-	756	WP_000861038.1	CHAP domain-containing protein	-
M2038_RS10380	2095107..2095361	-	255	WP_000611512.1	phage holin	-
M2038_RS10385	2095413..2095520	+	108	WP_001791821.1	hypothetical protein	-
-	2095442..2095581	+	140	NuclAT_0	-	-
-	2095442..2095581	+	140	NuclAT_0	-	-
-	2095442..2095581	+	140	NuclAT_0	-	-
-	2095442..2095581	+	140	NuclAT_0	-	-
-	2095450..2095505	+	56	-	-	Antitoxin
M2038_RS10390	2095573..2095749	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
M2038_RS10395	2095899..2096195	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
M2038_RS10400	2096253..2096540	-	288	WP_001040261.1	hypothetical protein	-
M2038_RS10405	2096587..2096739	-	153	WP_001153681.1	hypothetical protein	-
M2038_RS10410	2096729..2100514	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2091094..2147042	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T40658 WP_011447039.1 NZ_AP025693:c2095749-2095573 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T40658 NZ_AP025693:c2095749-2095573 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT40658 NZ_AP025693:2095450-2095505 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin