Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1934521..1934703 Replicon chromosome
Accession NZ_AP025693
Organism Staphylococcus aureus strain JICS127

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag M2038_RS09410 Protein ID WP_001801861.1
Coordinates 1934521..1934616 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1934644..1934703 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2038_RS09370 1930181..1930807 + 627 Protein_1848 hypothetical protein -
M2038_RS09375 1930848..1931192 + 345 WP_000627551.1 DUF3969 family protein -
M2038_RS09380 1931290..1931841 + 552 WP_000414205.1 hypothetical protein -
M2038_RS09385 1932059..1932700 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
M2038_RS09390 1932814..1932999 - 186 WP_000809857.1 hypothetical protein -
M2038_RS09395 1933001..1933177 - 177 WP_000375476.1 hypothetical protein -
M2038_RS09400 1933188..1933571 - 384 WP_000070811.1 hypothetical protein -
M2038_RS09405 1934175..1934318 - 144 WP_001549059.1 transposase -
M2038_RS09410 1934521..1934616 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1934644..1934703 - 60 - - Antitoxin
M2038_RS09415 1934739..1934840 + 102 WP_001791893.1 hypothetical protein -
M2038_RS09420 1934818..1934994 - 177 Protein_1858 transposase -
M2038_RS09425 1935188..1935565 - 378 WP_001037045.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA 1908495..1967791 59296


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T40655 WP_001801861.1 NZ_AP025693:1934521-1934616 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T40655 NZ_AP025693:1934521-1934616 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 60 bp

>AT40655 NZ_AP025693:c1934703-1934644 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References