Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1996546..1996961 Replicon chromosome
Accession NZ_AP025688
Organism Tsukamurella sp. PLM1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MTP03_RS10365 Protein ID WP_248491835.1
Coordinates 1996701..1996961 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MTP03_RS10360 Protein ID WP_248491834.1
Coordinates 1996546..1996704 (+) Length 53 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP03_RS10330 (MTP03_22070) 1991982..1992881 - 900 WP_248492120.1 amino acid ABC transporter permease -
MTP03_RS10335 (MTP03_22080) 1992998..1993609 - 612 WP_248492121.1 response regulator transcription factor -
MTP03_RS10340 (MTP03_22090) 1993673..1993984 - 312 WP_248491830.1 hypothetical protein -
MTP03_RS10345 (MTP03_22100) 1993981..1994757 - 777 WP_248491831.1 histidine kinase -
MTP03_RS10350 (MTP03_22110) 1994764..1995183 + 420 WP_248491832.1 hypothetical protein -
MTP03_RS10355 (MTP03_22120) 1995218..1996549 + 1332 WP_248491833.1 threonine ammonia-lyase IlvA -
MTP03_RS10360 (MTP03_22130) 1996546..1996704 + 159 WP_248491834.1 hypothetical protein Antitoxin
MTP03_RS10365 (MTP03_22140) 1996701..1996961 + 261 WP_248491835.1 Txe/YoeB family addiction module toxin Toxin
MTP03_RS10370 1997076..1997213 + 138 WP_248491836.1 hypothetical protein -
MTP03_RS10375 (MTP03_22150) 1997263..1997763 - 501 WP_248491837.1 hypothetical protein -
MTP03_RS10380 1997844..1998273 + 430 Protein_2081 PPOX class F420-dependent oxidoreductase -
MTP03_RS10385 (MTP03_22180) 1998934..1999959 - 1026 WP_248491838.1 LLM class flavin-dependent oxidoreductase -
MTP03_RS10390 (MTP03_22190) 2000027..2001067 - 1041 WP_248491839.1 LLM class F420-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9992.43 Da        Isoelectric Point: 9.7865

>T40649 WP_248491835.1 NZ_AP025688:1996701-1996961 [Tsukamurella sp. PLM1]
VRIVFTPQGWEDYVFWQQADRSLLKRINRLLADAARDPTGGIGKPEPLKYGIAGAWSRRINEEHRLVYQVPGDDLIVLQV
RYHYAK

Download         Length: 261 bp

>T40649 NZ_AP025688:1996701-1996961 [Tsukamurella sp. PLM1]
GTGAGGATCGTCTTCACCCCGCAGGGGTGGGAGGACTACGTCTTCTGGCAGCAGGCCGATCGCTCGTTGCTCAAGCGGAT
CAATCGGCTGCTGGCGGATGCTGCGCGCGACCCGACCGGAGGGATCGGGAAGCCCGAGCCGCTCAAGTACGGAATCGCCG
GTGCCTGGTCGCGTCGTATCAACGAGGAGCACCGGCTGGTGTATCAGGTGCCCGGCGATGACCTGATCGTCCTGCAGGTC
CGGTACCACTACGCGAAGTAG

Antitoxin


Download         Length: 53 a.a.        Molecular weight: 5653.00 Da        Isoelectric Point: 3.9169

>AT40649 WP_248491834.1 NZ_AP025688:1996546-1996704 [Tsukamurella sp. PLM1]
VTKDDGVANSGDESAWQETAYLFRSPANAQRLLDAAEAAERGEFAEHSLDLE

Download         Length: 159 bp

>AT40649 NZ_AP025688:1996546-1996704 [Tsukamurella sp. PLM1]
GTGACCAAGGACGACGGAGTGGCGAACTCGGGTGACGAATCGGCGTGGCAGGAGACCGCGTACCTGTTCCGCTCGCCGGC
GAATGCGCAGCGTCTGCTCGACGCCGCGGAGGCTGCGGAACGCGGCGAGTTCGCGGAGCATTCGCTGGATCTCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References