40647

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2514009..2514532 Replicon chromosome
Accession NZ_AP025683
Organism Staphylococcus aureus strain JP025

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag SAJP025_RS12420 Protein ID WP_000074047.1
Coordinates 2514009..2514275 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag SAJP025_RS12425 Protein ID WP_000587617.1
Coordinates 2514275..2514532 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAJP025_RS12400 (2509219) 2509219..2510406 - 1188 WP_000026190.1 MFS transporter -
SAJP025_RS12405 (2510800) 2510800..2511576 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
SAJP025_RS12410 (2511569) 2511569..2512231 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
SAJP025_RS12415 (2512577) 2512577..2513653 - 1077 WP_001076679.1 M42 family metallopeptidase -
SAJP025_RS12420 (2514009) 2514009..2514275 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
SAJP025_RS12425 (2514275) 2514275..2514532 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAJP025_RS12430 (2514892) 2514892..2515347 + 456 WP_000732090.1 YehR family lipoprotein -
SAJP025_RS12435 (2515515) 2515515..2517092 - 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
SAJP025_RS12440 (2517288) 2517288..2518037 + 750 WP_000072447.1 CPBP family lipoprotein N-acylation protein LnsB -
SAJP025_RS12445 (2518261) 2518261..2519454 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T40647 WP_000074047.1 NZ_AP025683:c2514275-2514009 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T40647 NZ_AP025683:c2514275-2514009 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGATCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT40647 WP_000587617.1 NZ_AP025683:c2514532-2514275 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT40647 NZ_AP025683:c2514532-2514275 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References