Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2482694..2482878 Replicon chromosome
Accession NZ_AP025683
Organism Staphylococcus aureus strain JP025

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag SAJP025_RS12280 Protein ID WP_000482647.1
Coordinates 2482771..2482878 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2482694..2482754 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAJP025_RS12265 2478204..2478371 - 168 Protein_2375 hypothetical protein -
SAJP025_RS12270 2478602..2480335 - 1734 WP_000486505.1 ABC transporter ATP-binding protein -
SAJP025_RS12275 2480360..2482123 - 1764 WP_001064829.1 ABC transporter ATP-binding protein -
- 2482694..2482754 + 61 - - Antitoxin
SAJP025_RS12280 2482771..2482878 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
SAJP025_RS12285 2483012..2483398 - 387 WP_000779351.1 flippase GtxA -
SAJP025_RS12290 2483666..2484808 + 1143 WP_001176856.1 glycerate kinase -
SAJP025_RS12295 2484868..2485527 + 660 WP_000831298.1 membrane protein -
SAJP025_RS12300 2485709..2486920 + 1212 WP_001191920.1 multidrug effflux MFS transporter -
SAJP025_RS12305 2487043..2487516 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T40645 WP_000482647.1 NZ_AP025683:c2482878-2482771 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T40645 NZ_AP025683:c2482878-2482771 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT40645 NZ_AP025683:2482694-2482754 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References