Detailed information of TA system TA040636

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2046297..2046604
• Replicon: chromosome
• Accession: NZ_AP025683
• Organism: Staphylococcus aureus strain JP025

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAJP025_RS10035
• Protein ID: WP_011447039.1
• Coordinates: 2046428..2046604 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2046297..2046436 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAJP025_RS09995 (2041636)	2041636..2041896	+	261	WP_001791826.1	hypothetical protein	-
SAJP025_RS10000 (2041949)	2041949..2042299	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAJP025_RS10005 (2042984)	2042984..2043433	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
SAJP025_RS10010 (2043528)	2043528..2043863	-	336	Protein_1937	SH3 domain-containing protein	-
SAJP025_RS10015 (2044513)	2044513..2045004	-	492	WP_000919350.1	staphylokinase	-
SAJP025_RS10020 (2045195)	2045195..2045950	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAJP025_RS10025 (2045962)	2045962..2046216	-	255	WP_000611512.1	phage holin	-
SAJP025_RS10030 (2046268)	2046268..2046375	+	108	WP_031878979.1	hypothetical protein	-
- (2046297)	2046297..2046436	+	140	NuclAT_0	-	Antitoxin
- (2046297)	2046297..2046436	+	140	NuclAT_0	-	Antitoxin
- (2046297)	2046297..2046436	+	140	NuclAT_0	-	Antitoxin
- (2046297)	2046297..2046436	+	140	NuclAT_0	-	Antitoxin
SAJP025_RS10035 (2046428)	2046428..2046604	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
SAJP025_RS10040 (2046754)	2046754..2047050	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SAJP025_RS10045 (2047108)	2047108..2047395	-	288	WP_001040261.1	hypothetical protein	-
SAJP025_RS10050 (2047442)	2047442..2047594	-	153	WP_001153681.1	hypothetical protein	-
SAJP025_RS10055 (2047584)	2047584..2051369	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2041949..2073346	31397

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T40636 WP_011447039.1 NZ_AP025683:c2046604-2046428 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T40636 NZ_AP025683:c2046604-2046428 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT40636 NZ_AP025683:2046297-2046436 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCTCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin