Detailed information of TA system TA040629

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1561789..1562368
• Replicon: chromosome
• Accession: NZ_AP025683
• Organism: Staphylococcus aureus strain JP025

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAJP025_RS07425
• Protein ID: WP_001025401.1
• Coordinates: 1562123..1562368 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1561789..1562154 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAJP025_RS07385 (1558532)	1558532..1559089	-	558	WP_000645042.1	DUF2815 family protein	-
SAJP025_RS07390 (1559115)	1559115..1560281	-	1167	WP_000762532.1	DUF2800 domain-containing protein	-
SAJP025_RS07395 (1560278)	1560278..1560640	-	363	WP_000279449.1	hypothetical protein	-
SAJP025_RS07400 (1560655)	1560655..1560978	-	324	WP_000175000.1	hypothetical protein	-
SAJP025_RS07405 (1561057)	1561057..1561218	-	162	WP_001285963.1	DUF1270 family protein	-
SAJP025_RS07410 (1561231)	1561231..1561494	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
SAJP025_RS07415 (1561519)	1561519..1561734	-	216	WP_001036302.1	hypothetical protein	-
SAJP025_RS07420 (1561789)	1561789..1562154	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SAJP025_RS07425 (1562123)	1562123..1562368	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAJP025_RS07430 (1562424)	1562424..1562633	+	210	WP_000642492.1	hypothetical protein	-
SAJP025_RS07435 (1562623)	1562623..1562766	-	144	WP_000939498.1	hypothetical protein	-
SAJP025_RS07440 (1562795)	1562795..1563571	-	777	WP_001148544.1	Rha family transcriptional regulator	-
SAJP025_RS07445 (1563585)	1563585..1563821	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
SAJP025_RS07450 (1563973)	1563973..1564287	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
SAJP025_RS07455 (1564300)	1564300..1564761	+	462	WP_000525004.1	hypothetical protein	-
SAJP025_RS07460 (1564779)	1564779..1565363	+	585	WP_000825948.1	hypothetical protein	-
SAJP025_RS07465 (1565593)	1565593..1565739	+	147	WP_001013104.1	hypothetical protein	-
SAJP025_RS07470 (1565736)	1565736..1566350	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	1521593..1580456	58863

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T40629 WP_001025401.1 NZ_AP025683:c1562368-1562123 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T40629 NZ_AP025683:c1562368-1562123 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT40629 NZ_AP025683:1561789-1562154 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin