Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4033096..4033354 Replicon chromosome
Accession NZ_AP025682
Organism Escherichia coli strain Rb-50

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag EcoliRb_RS19460 Protein ID WP_000809168.1
Coordinates 4033202..4033354 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4033096..4033153 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EcoliRb_RS19445 4028940..4030184 - 1245 WP_244331579.1 cytoplasmic protein -
EcoliRb_RS19450 4030313..4031806 - 1494 WP_244331581.1 sulfatase-like hydrolase/transferase -
EcoliRb_RS19455 4031826..4032587 - 762 WP_105495377.1 outer membrane protein OmpK -
- 4033096..4033153 - 58 - - Antitoxin
EcoliRb_RS19460 4033202..4033354 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
EcoliRb_RS19465 4033458..4034588 - 1131 WP_001118464.1 molecular chaperone DnaJ -
EcoliRb_RS19470 4034677..4036593 - 1917 WP_000516135.1 molecular chaperone DnaK -
EcoliRb_RS19475 4036965..4037369 + 405 WP_001357545.1 DUF2541 family protein -
EcoliRb_RS19480 4037395..4038108 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - espX1 4021225..4033354 12129


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T40623 WP_000809168.1 NZ_AP025682:4033202-4033354 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T40623 NZ_AP025682:4033202-4033354 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT40623 NZ_AP025682:c4033153-4033096 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References