Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4091681..4091939 Replicon chromosome
Accession NZ_AP025662
Organism Escherichia coli strain TUM20902

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag M2084_RS19550 Protein ID WP_000809168.1
Coordinates 4091787..4091939 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4091681..4091738 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2084_RS19535 4088073..4089032 + 960 WP_000871674.1 hypothetical protein -
M2084_RS19540 4089070..4089969 - 900 WP_001300855.1 transcriptional activator NhaR -
M2084_RS19545 4090035..4091201 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4091681..4091738 - 58 - - Antitoxin
M2084_RS19550 4091787..4091939 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
M2084_RS19555 4092043..4093173 - 1131 WP_001118464.1 molecular chaperone DnaJ -
M2084_RS19560 4093262..4095178 - 1917 WP_000516135.1 molecular chaperone DnaK -
M2084_RS19565 4095554..4095958 + 405 WP_000843584.1 DUF2541 family protein -
M2084_RS19570 4095984..4096697 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T40528 WP_000809168.1 NZ_AP025662:4091787-4091939 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T40528 NZ_AP025662:4091787-4091939 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT40528 NZ_AP025662:c4091738-4091681 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References