Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4092219..4092477 Replicon chromosome
Accession NZ_AP025657
Organism Escherichia coli strain TUM13867

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag MWM17_RS19565 Protein ID WP_000809168.1
Coordinates 4092325..4092477 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4092219..4092276 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWM17_RS19550 4088611..4089570 + 960 WP_000871674.1 hypothetical protein -
MWM17_RS19555 4089608..4090507 - 900 WP_001300855.1 transcriptional activator NhaR -
MWM17_RS19560 4090573..4091739 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4092219..4092276 - 58 - - Antitoxin
MWM17_RS19565 4092325..4092477 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
MWM17_RS19570 4092581..4093711 - 1131 WP_001118464.1 molecular chaperone DnaJ -
MWM17_RS19575 4093800..4095716 - 1917 WP_000516135.1 molecular chaperone DnaK -
MWM17_RS19580 4096092..4096496 + 405 WP_000843584.1 DUF2541 family protein -
MWM17_RS19585 4096522..4097235 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T40494 WP_000809168.1 NZ_AP025657:4092325-4092477 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T40494 NZ_AP025657:4092325-4092477 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT40494 NZ_AP025657:c4092276-4092219 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References