40472

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 739028..739721 Replicon chromosome
Accession NZ_AP025657
Organism Escherichia coli strain TUM13867

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag MWM17_RS03590 Protein ID WP_000415584.1
Coordinates 739028..739324 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MWM17_RS03595 Protein ID WP_000650107.1
Coordinates 739326..739721 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWM17_RS03555 (734107) 734107..734421 - 315 WP_000958598.1 putative quinol monooxygenase -
MWM17_RS03560 (734452) 734452..735033 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
MWM17_RS03565 (735361) 735361..735693 + 333 WP_000917684.1 DUF2645 family protein -
MWM17_RS03570 (735739) 735739..737088 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
MWM17_RS03575 (737085) 737085..737744 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
MWM17_RS03580 (737896) 737896..738288 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MWM17_RS03585 (738341) 738341..738823 + 483 WP_000183505.1 GyrI-like domain-containing protein -
MWM17_RS03590 (739028) 739028..739324 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
MWM17_RS03595 (739326) 739326..739721 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MWM17_RS03600 (739854) 739854..741461 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
MWM17_RS03605 (741599) 741599..743857 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T40472 WP_000415584.1 NZ_AP025657:739028-739324 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T40472 NZ_AP025657:739028-739324 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT40472 WP_000650107.1 NZ_AP025657:739326-739721 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT40472 NZ_AP025657:739326-739721 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References