Detailed information of TA system TA040447

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2111934..2112439
• Replicon: chromosome
• Accession: NZ_AP025590
• Organism: Actinomyces oris K20

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: AoKodu_RS09005
• Protein ID: WP_010613471.1
• Coordinates: 2111934..2112200 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1F1VSH2
• Locus tag: AoKodu_RS09010
• Protein ID: WP_029316340.1
• Coordinates: 2112197..2112439 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AoKodu_RS08990 (AoKodu_18070)	2109824..2110039	+	216	WP_009407243.1	DUF3107 domain-containing protein	-
AoKodu_RS08995 (AoKodu_18080)	2110177..2110932	+	756	WP_010613473.1	NAD-dependent protein deacylase	-
AoKodu_RS09000 (AoKodu_18090)	2110929..2111768	-	840	WP_010613472.1	polyphosphate kinase 2	-
AoKodu_RS09005 (AoKodu_18100)	2111934..2112200	-	267	WP_010613471.1	Txe/YoeB family addiction module toxin	Toxin
AoKodu_RS09010 (AoKodu_18110)	2112197..2112439	-	243	WP_029316340.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AoKodu_RS09020 (AoKodu_18120)	2112755..2115961	-	3207	WP_029316339.1	UPF0182 family protein	-
AoKodu_RS09025 (AoKodu_18140)	2116212..2116793	+	582	WP_248407081.1	PPA1309 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10466.19 Da
• Isoelectric Point: 10.5624

>T40447 WP_010613471.1 NZ_AP025590:c2112200-2111934 [Actinomyces oris K20]
VSSWRIVFSRQAQKDAKKLTAAGLKPKTEKLLNLMRENPFVKPPRYEKLVGDLSGCYSRRITIQHRLVYEVHTDERTIHV
LRMWTHYE

Nucleotide

• Length: 267 bp

>T40447 NZ_AP025590:c2112200-2111934 [Actinomyces oris K20]
GTGAGCTCGTGGCGAATCGTGTTCTCACGTCAGGCACAGAAGGATGCGAAGAAACTCACCGCGGCGGGGCTCAAGCCTAA
AACCGAGAAGCTCCTCAACCTCATGCGGGAGAATCCCTTCGTCAAGCCGCCTCGTTATGAAAAGCTGGTTGGGGATCTAT
CGGGCTGCTACTCGCGGCGTATCACTATCCAGCATCGACTCGTCTACGAGGTGCATACCGACGAGAGGACCATCCATGTC
CTGAGAATGTGGACCCACTACGAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8975.97 Da
• Isoelectric Point: 4.0078

>AT40447 WP_029316340.1 NZ_AP025590:c2112439-2112197 [Actinomyces oris K20]
VSTIPVTTARSQLYRLIDQVNEDSEPLVITGQRGNAVLVGEEDWRAIQETLYLESVPGMMDSIRNARREGIEAGSEELDW

Nucleotide

• Length: 243 bp

>AT40447 NZ_AP025590:c2112439-2112197 [Actinomyces oris K20]
GTGTCTACGATTCCAGTGACGACCGCTCGTTCTCAGTTGTATCGGCTCATCGATCAGGTCAACGAAGACTCCGAGCCGCT
GGTCATCACCGGCCAACGCGGCAATGCCGTCTTGGTGGGGGAGGAGGACTGGAGGGCGATCCAGGAGACGCTCTACCTGG
AGTCCGTCCCGGGCATGATGGACTCGATCCGGAATGCCCGACGTGAAGGCATCGAGGCGGGCTCGGAAGAACTCGACTGG
TGA

Structures

Antitoxin

• AlphaFold DB: A0A1F1VSH2