Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 884835..885652 Replicon chromosome
Accession NZ_AP025556
Organism Delftia lacustris strain HQS1

Toxin (Protein)


Gene name yhaV Uniprot ID A0A6N8S4E7
Locus tag HQS1_RS03990 Protein ID WP_034363310.1
Coordinates 884835..885326 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A031I1Z5
Locus tag HQS1_RS03995 Protein ID WP_016452695.1
Coordinates 885323..885652 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQS1_RS03960 (HQS1_07780) 879961..880446 + 486 WP_026062693.1 cobalamin biosynthesis protein -
HQS1_RS03965 (HQS1_07790) 880443..881321 + 879 WP_244387787.1 precorrin-4 C(11)-methyltransferase -
HQS1_RS03970 (HQS1_07800) 881318..882115 + 798 WP_034363307.1 precorrin-6A synthase (deacetylating) -
HQS1_RS03975 (HQS1_07810) 882179..882508 + 330 WP_013800515.1 DHCW motif cupin fold protein -
HQS1_RS03980 (HQS1_07820) 882784..884193 + 1410 WP_244387788.1 chloride channel protein -
HQS1_RS03985 (HQS1_07830) 884308..884820 + 513 WP_016448386.1 MgtC/SapB family protein -
HQS1_RS03990 (HQS1_07840) 884835..885326 - 492 WP_034363310.1 type II toxin-antitoxin system YhaV family toxin Toxin
HQS1_RS03995 (HQS1_07850) 885323..885652 - 330 WP_016452695.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
HQS1_RS04000 (HQS1_07860) 885750..887990 - 2241 WP_244387789.1 TonB-dependent receptor -
HQS1_RS04005 (HQS1_07870) 888114..888509 - 396 WP_034363313.1 hypothetical protein -
HQS1_RS04010 (HQS1_07880) 888538..889200 - 663 WP_034363316.1 pyridoxamine 5'-phosphate oxidase family protein -
HQS1_RS04015 (HQS1_07890) 889271..890101 + 831 WP_141835639.1 helix-turn-helix transcriptional regulator -
HQS1_RS04020 (HQS1_07900) 890191..890460 + 270 WP_012207631.1 type II toxin-antitoxin system ParD family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-107)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18763.37 Da        Isoelectric Point: 10.2214

>T40417 WP_034363310.1 NZ_AP025556:c885326-884835 [Delftia lacustris]
MSAVPPAPLRIHGWTVFMHPLFLAQLQALSQEVEGLKTKDPGGYTRKNATKRLAAIRKLAFDVIPQDPTRPDYRQGHTLG
EEHKHWFRARFFQQYRLFFRFHAPSKIIVFAWVNDEDTKRAYEGSDDAYRVFRKMLANGHPPGDWDSLLAQAKSPPPDSQ
PHA

Download         Length: 492 bp

>T40417 NZ_AP025556:c885326-884835 [Delftia lacustris]
ATGAGCGCCGTACCGCCCGCCCCCTTGCGCATCCACGGCTGGACGGTATTCATGCACCCGCTTTTCCTGGCCCAGCTGCA
GGCGTTGAGCCAGGAAGTGGAGGGTCTGAAAACCAAGGACCCTGGCGGGTACACACGCAAGAACGCGACCAAGCGATTGG
CGGCGATCCGCAAGCTGGCATTCGATGTCATCCCGCAGGATCCGACGCGGCCAGACTACCGCCAGGGCCATACCCTGGGC
GAGGAGCACAAGCACTGGTTTCGGGCCAGGTTCTTCCAGCAGTACCGCCTGTTCTTTCGCTTTCACGCCCCCAGCAAAAT
CATCGTGTTCGCCTGGGTCAACGATGAGGACACCAAGCGAGCCTATGAGGGCAGCGACGATGCCTACAGGGTGTTCCGAA
AAATGCTCGCCAACGGGCACCCTCCTGGCGATTGGGACAGTTTGCTGGCACAGGCGAAGTCCCCGCCACCCGACTCACAG
CCGCACGCCTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12036.45 Da        Isoelectric Point: 4.1858

>AT40417 WP_016452695.1 NZ_AP025556:c885652-885323 [Delftia lacustris]
MFSTLEAESTLTDRYQTTIPEAVRRALHLSKRDRIHYTILPGGEVVLSRADSAEDADPVLGQFLGFLAQDMAAHPERLQT
MDARLAQQIQALTEGIEVDLDAPLSADDE

Download         Length: 330 bp

>AT40417 NZ_AP025556:c885652-885323 [Delftia lacustris]
ATGTTTTCGACACTTGAAGCCGAATCCACGCTCACTGACCGCTACCAGACCACCATTCCCGAAGCCGTTCGCCGCGCATT
GCACCTGAGCAAGCGCGACAGGATCCACTACACCATCCTGCCCGGCGGTGAGGTCGTTCTCAGTCGCGCCGACTCCGCCG
AGGATGCCGATCCCGTGCTGGGCCAGTTTCTCGGCTTTCTGGCACAGGACATGGCAGCCCACCCCGAGCGCCTGCAGACC
ATGGATGCCCGTCTGGCGCAGCAGATCCAGGCGCTGACCGAAGGCATCGAGGTCGATCTGGATGCACCGCTTTCGGCAGA
CGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N8S4E7

Antitoxin

Source ID Structure
AlphaFold DB A0A031I1Z5

References