Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 715734..716427 Replicon chromosome
Accession NZ_AP025551
Organism Escherichia coli strain LR-50

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QUE19_RS03480 Protein ID WP_000415584.1
Coordinates 715734..716030 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QUE19_RS03485 Protein ID WP_000650107.1
Coordinates 716032..716427 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE19_RS03445 (710822) 710822..711136 - 315 WP_000958598.1 putative quinol monooxygenase -
QUE19_RS03450 (711167) 711167..711748 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QUE19_RS03455 (712067) 712067..712399 + 333 WP_000917684.1 DUF2645 family protein -
QUE19_RS03460 (712445) 712445..713794 - 1350 WP_247767145.1 quorum sensing histidine kinase QseC -
QUE19_RS03465 (713791) 713791..714450 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QUE19_RS03470 (714602) 714602..714994 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QUE19_RS03475 (715047) 715047..715529 + 483 WP_112913378.1 GyrI-like domain-containing protein -
QUE19_RS03480 (715734) 715734..716030 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QUE19_RS03485 (716032) 716032..716427 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QUE19_RS03490 (716560) 716560..718167 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QUE19_RS03495 (718305) 718305..720563 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T40398 WP_000415584.1 NZ_AP025551:715734-716030 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T40398 NZ_AP025551:715734-716030 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT40398 WP_000650107.1 NZ_AP025551:716032-716427 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT40398 NZ_AP025551:716032-716427 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References