Detailed information of TA system TA040370

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 24262..24920
• Replicon: plasmid pOCUAc19-1
• Accession: NZ_AP025532
• Organism: Acinetobacter baumannii strain OCU-Ac19

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: QMN04_RS18975
• Protein ID: WP_000312250.1
• Coordinates: 24561..24920 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: QMN04_RS18970
• Protein ID: WP_001096429.1
• Coordinates: 24262..24561 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMN04_RS18935 (OCUAc19_36990)	20322..20579	+	258	WP_000834292.1	hypothetical protein	-
QMN04_RS18940 (OCUAc19_37000)	20584..21156	+	573	WP_032011345.1	hypothetical protein	-
QMN04_RS18945 (OCUAc19_37010)	21132..21311	+	180	WP_002081921.1	hypothetical protein	-
QMN04_RS18950 (OCUAc19_37020)	21328..21957	+	630	WP_002081923.1	hypothetical protein	-
QMN04_RS18955 (OCUAc19_37030)	21997..22506	+	510	WP_032018705.1	hypothetical protein	-
QMN04_RS18960 (OCUAc19_37040)	22587..23141	+	555	WP_000790086.1	hypothetical protein	-
QMN04_RS18965 (OCUAc19_37050)	23191..23535	+	345	WP_281977265.1	hypothetical protein	-
QMN04_RS18970 (OCUAc19_37070)	24262..24561	-	300	WP_001096429.1	XRE family transcriptional regulator	Antitoxin
QMN04_RS18975 (OCUAc19_37080)	24561..24920	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QMN04_RS18980 (OCUAc19_37090)	25121..25687	+	567	WP_031948745.1	hypothetical protein	-
QMN04_RS18985 (OCUAc19_37100)	25736..25966	+	231	WP_045124240.1	hypothetical protein	-
QMN04_RS18990 (OCUAc19_37110)	25985..26683	+	699	WP_000873188.1	hypothetical protein	-
QMN04_RS18995 (OCUAc19_37120)	26821..27204	+	384	WP_032018724.1	hypothetical protein	-
QMN04_RS19000 (OCUAc19_37130)	27271..28029	+	759	WP_001053130.1	hypothetical protein	-
QMN04_RS19005 (OCUAc19_37140)	28081..28416	+	336	WP_000654056.1	hypothetical protein	-
QMN04_RS19010 (OCUAc19_37150)	29281..29595	+	315	WP_032011240.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..71826	71826

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T40370 WP_000312250.1 NZ_AP025532:c24920-24561 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T40370 NZ_AP025532:c24920-24561 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT40370 WP_001096429.1 NZ_AP025532:c24561-24262 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT40370 NZ_AP025532:c24561-24262 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA