Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 277580..278213 Replicon chromosome
Accession NZ_AP025511
Organism Vibrio tasmaniensis strain LMG 20012

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OCV44_RS15615 Protein ID WP_139684434.1
Coordinates 277881..278213 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OCV44_RS15610 Protein ID WP_139684389.1
Coordinates 277580..277894 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV44_RS15585 273009..274484 + 1476 WP_139684393.1 phosphomannomutase CpsG -
OCV44_RS15590 274599..275651 - 1053 WP_139684392.1 3-deoxy-7-phosphoheptulonate synthase AroG -
OCV44_RS15595 276173..276703 - 531 WP_139684391.1 GNAT family N-acetyltransferase -
OCV44_RS15600 276700..276969 - 270 WP_139684390.1 DUF1778 domain-containing protein -
OCV44_RS15605 277118..277420 + 303 Protein_236 transposase -
OCV44_RS15610 277580..277894 - 315 WP_139684389.1 DNA-binding transcriptional regulator Antitoxin
OCV44_RS15615 277881..278213 - 333 WP_139684434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCV44_RS15620 278674..279480 - 807 WP_139684388.1 hypothetical protein -
OCV44_RS15625 280004..280222 - 219 WP_009845653.1 DUF3820 family protein -
OCV44_RS15630 280235..280906 - 672 WP_139684387.1 DUF3313 domain-containing protein -
OCV44_RS15635 281003..281356 - 354 WP_065099595.1 L-threonine 3-dehydrogenase -
OCV44_RS15640 281521..282495 - 975 WP_139684386.1 heme o synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12934.81 Da        Isoelectric Point: 10.0960

>T40344 WP_139684434.1 NZ_AP025511:c278213-277881 [Vibrio tasmaniensis]
MKSVFVESTIFEKYRNEYLSDDEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVLYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKVFMEAWRNEQS

Download         Length: 333 bp

>T40344 NZ_AP025511:c278213-277881 [Vibrio tasmaniensis]
ATGAAAAGTGTATTTGTTGAATCGACCATATTTGAAAAGTACCGTAATGAATATCTCAGCGATGATGAGTTTAGGCTTTT
TCAAGCTGAGTTAATGTCTAACCCGAAACAGGGGGACGTGATTCAAGGTACAGGTGGTTTGCGAAAGATTCGAGTTGCAA
GTAAAGGTAAGGGCAAGCGAGGCGGCTCTCGTGTTCTCTATTACTTCCTCGATGAAAAGCGTCGCTTCTACTTGCTGACA
ATTTATGGCAAGAATGAAATGTCTGATTTAACTGCAGATCAAAAGAAACAATTAAAGGTTTTTATGGAGGCGTGGCGTAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11738.19 Da        Isoelectric Point: 6.3290

>AT40344 WP_139684389.1 NZ_AP025511:c277894-277580 [Vibrio tasmaniensis]
MSNRDLFAELSSALVEAKEHSEGKFTLKTHQVNDISELDISPNEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT40344 NZ_AP025511:c277894-277580 [Vibrio tasmaniensis]
ATGAGCAATCGTGATCTATTTGCAGAGTTAAGTTCTGCTCTTGTTGAGGCTAAAGAGCATTCAGAGGGTAAATTCACTCT
TAAAACTCATCAAGTTAACGATATCAGTGAGTTAGATATTTCACCTAATGAGATCGTGAGTATCCGTGAACAGTTTAATA
TGTCGCGTGGTGTGTTTGCGCGTTTACTGCATACATCATCCCGAACATTAGAAAACTGGGAACAAGGGCGTAGCGCACCA
AATGGACAAGCTGTGACCCTTCTAAAATTGGTTCAGCGTCATCCGGAAACTCTTTCGCACATCGCTGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References