Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1865867..1866611 Replicon chromosome
Accession NZ_AP025480
Organism Vibrio cyclitrophicus strain LMG 21359

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OCW38_RS08080 Protein ID WP_261893655.1
Coordinates 1866294..1866611 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OCW38_RS08075 Protein ID WP_017102429.1
Coordinates 1865867..1866289 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCW38_RS08055 1862173..1862946 - 774 WP_261893647.1 hypothetical protein -
OCW38_RS08060 1862976..1863857 - 882 WP_261893649.1 radical SAM protein -
OCW38_RS08065 1864040..1864246 - 207 WP_017101642.1 AlpA family transcriptional regulator -
OCW38_RS08070 1864344..1865750 - 1407 WP_038224876.1 IS66 family transposase -
OCW38_RS08075 1865867..1866289 - 423 WP_017102429.1 helix-turn-helix domain-containing protein Antitoxin
OCW38_RS08080 1866294..1866611 - 318 WP_261893655.1 type II toxin-antitoxin system HigB family toxin Toxin
OCW38_RS08085 1866855..1867046 - 192 WP_102573182.1 AlpA family transcriptional regulator -
OCW38_RS08090 1867222..1868463 - 1242 WP_261893658.1 integrase domain-containing protein -
OCW38_RS08100 1868979..1869647 - 669 WP_010441166.1 DUF2726 domain-containing protein -
OCW38_RS08105 1869921..1870106 + 186 WP_010441167.1 hypothetical protein -
OCW38_RS08110 1870306..1870467 - 162 WP_022570743.1 GGDEF domain protein -
OCW38_RS08115 1870503..1871111 - 609 Protein_1543 GGDEF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-138)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12394.34 Da        Isoelectric Point: 10.1226

>T40317 WP_261893655.1 NZ_AP025480:c1866611-1866294 [Vibrio cyclitrophicus]
MHVISKQPFENAKKLYPNDSDALDATYKVLKESKAKSPDELRKVFPSLDNFKYVDKWWVIDIGGNNLRLIAFIEFVGGRC
FIKNIVSHAEYDRITKQYREKKLRR

Download         Length: 318 bp

>T40317 NZ_AP025480:c1866611-1866294 [Vibrio cyclitrophicus]
ATGCACGTTATAAGTAAGCAACCTTTTGAAAATGCGAAAAAACTCTATCCAAACGATTCCGATGCACTAGATGCAACGTA
CAAGGTGTTAAAAGAGAGTAAAGCAAAAAGCCCAGATGAGCTACGAAAGGTCTTTCCGTCACTAGACAATTTTAAATACG
TTGATAAGTGGTGGGTGATTGATATTGGCGGTAACAACTTAAGGCTTATTGCATTTATCGAATTTGTAGGAGGTCGATGC
TTCATTAAGAACATTGTCAGCCATGCCGAGTACGACCGTATTACAAAGCAATACCGTGAAAAGAAACTGAGGAGGTAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15676.05 Da        Isoelectric Point: 4.2521

>AT40317 WP_017102429.1 NZ_AP025480:c1866289-1865867 [Vibrio cyclitrophicus]
MLDIAVLDKAANQLNQVMPWVSGISSPEQYQELIATMEVLIEDYDAHQPVIDLMFPVIERYEEEAEQFSEFNQAIDKLEP
GIAMLRVIIDQHQLTLSDFKEEIGAKSTVSMILSGKRALTLNHIKALSARFGVPASLFIG

Download         Length: 423 bp

>AT40317 NZ_AP025480:c1866289-1865867 [Vibrio cyclitrophicus]
ATGTTAGATATCGCTGTGTTAGACAAAGCCGCTAATCAACTGAACCAAGTTATGCCTTGGGTGAGTGGTATCTCTTCGCC
TGAGCAATATCAAGAGCTGATTGCCACGATGGAAGTACTTATCGAAGATTATGATGCTCATCAGCCAGTGATTGACTTGA
TGTTTCCGGTGATTGAAAGGTATGAAGAAGAAGCGGAGCAGTTTAGTGAATTTAATCAAGCTATTGATAAGCTTGAGCCT
GGCATCGCCATGCTAAGAGTTATCATCGATCAGCATCAATTGACATTAAGTGACTTCAAAGAAGAGATTGGTGCAAAATC
GACGGTATCAATGATCTTGAGTGGGAAGCGCGCTCTAACGCTCAACCACATTAAGGCACTATCGGCGCGCTTTGGTGTGC
CAGCGTCATTGTTTATCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References