40225

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2691161..2691497 Replicon chromosome
Accession NZ_AP025270
Organism Enterococcus faecalis strain K-4

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag EFK4_RS12895 Protein ID WP_002381035.1
Coordinates 2691161..2691304 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2691448..2691497 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFK4_RS12875 2686283..2686498 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
EFK4_RS12880 2686637..2687629 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
EFK4_RS12885 2687893..2688522 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
EFK4_RS12890 2689215..2690831 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
EFK4_RS12895 2691161..2691304 + 144 WP_002381035.1 putative holin-like toxin Toxin
- 2691448..2691497 + 50 - - Antitoxin
EFK4_RS12900 2691499..2696190 - 4692 WP_236919338.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T40225 WP_002381035.1 NZ_AP025270:2691161-2691304 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

>T40225 NZ_AP025270:2691161-2691304 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 50 bp

>AT40225 NZ_AP025270:2691448-2691497 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References