Detailed information of TA system TA040211

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2539113..2539373
• Replicon: chromosome
• Accession: NZ_AP025270
• Organism: Enterococcus faecalis strain K-4

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: EFK4_RS12210
• Protein ID: WP_075551663.1
• Coordinates: 2539272..2539373 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2539113..2539323 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EFK4_RS12185	2534797..2535750	-	954	WP_002354964.1	siderophore ABC transporter substrate-binding protein	-
EFK4_RS12190	2535789..2536544	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
EFK4_RS12195	2536541..2537506	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
EFK4_RS12200	2537503..2538450	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
EFK4_RS12205	2538635..2539087	+	453	WP_002354958.1	YueI family protein	-
-	2539113..2539323	+	211	-	-	Antitoxin
EFK4_RS12210	2539272..2539373	-	102	WP_075551663.1	putative holin-like toxin	Toxin
EFK4_RS12215	2539562..2541832	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
EFK4_RS12220	2542003..2542503	+	501	WP_002354954.1	cysteine hydrolase family protein	-
EFK4_RS12225	2543050..2543936	+	887	Protein_2385	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T40211 WP_075551663.1 NZ_AP025270:c2539373-2539272 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T40211 NZ_AP025270:c2539373-2539272 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 211 bp

>AT40211 NZ_AP025270:2539113-2539323 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGT
TATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin