Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 697735..698428 Replicon chromosome
Accession NZ_AP025220
Organism Escherichia coli strain 2017.11.01CC

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LPH31_RS03430 Protein ID WP_000415584.1
Coordinates 697735..698031 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LPH31_RS03435 Protein ID WP_000650107.1
Coordinates 698033..698428 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPH31_RS03395 (692823) 692823..693137 - 315 WP_000958598.1 putative quinol monooxygenase -
LPH31_RS03400 (693168) 693168..693749 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LPH31_RS03405 (694068) 694068..694400 + 333 WP_229430225.1 DUF2645 family protein -
LPH31_RS03410 (694446) 694446..695795 - 1350 WP_000673409.1 quorum sensing histidine kinase QseC -
LPH31_RS03415 (695792) 695792..696451 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LPH31_RS03420 (696603) 696603..696995 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LPH31_RS03425 (697048) 697048..697530 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LPH31_RS03430 (697735) 697735..698031 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LPH31_RS03435 (698033) 698033..698428 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LPH31_RS03440 (698561) 698561..700168 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LPH31_RS03445 (700306) 700306..702564 + 2259 WP_072777792.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T40146 WP_000415584.1 NZ_AP025220:697735-698031 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T40146 NZ_AP025220:697735-698031 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT40146 WP_000650107.1 NZ_AP025220:698033-698428 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT40146 NZ_AP025220:698033-698428 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References