Detailed information of TA system TA040135

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3177556..3177778
• Replicon: chromosome
• Accession: NZ_AP025214
• Organism: Escherichia coli strain 2017.09.02CC

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A4T4QR47
• Locus tag: LPH32_RS15515
• Protein ID: WP_000170735.1
• Coordinates: 3177671..3177778 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3177556..3177614 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH32_RS15490	3172944..3173927	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
LPH32_RS15495	3173924..3174928	+	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
LPH32_RS15500	3174958..3176229	-	1272	WP_001318103.1	aromatic amino acid transport family protein	-
LPH32_RS15505	3176705..3176812	+	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	-
LPH32_RS15510	3177188..3177295	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	3177556..3177614	-	59	-	-	Antitoxin
LPH32_RS15515	3177671..3177778	+	108	WP_000170735.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
LPH32_RS15520	3177865..3179544	-	1680	WP_053290823.1	cellulose biosynthesis protein BcsG	-
LPH32_RS15525	3179541..3179732	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
LPH32_RS15530	3179729..3181300	-	1572	WP_072153691.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
LPH32_RS15535	3181573..3181761	+	189	WP_001063315.1	cellulose biosynthesis protein BcsR	-
LPH32_RS15540	3181773..3182525	+	753	WP_000279544.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3896.73 Da
• Isoelectric Point: 9.0157

>T40135 WP_000170735.1 NZ_AP025214:3177671-3177778 [Escherichia coli]
MTLAELGMAFWHDLAAPIIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T40135 NZ_AP025214:3177671-3177778 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGATCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT40135 NZ_AP025214:c3177614-3177556 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4T4QR47

Antitoxin