Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2054917..2055610 Replicon chromosome
Accession NZ_AP025180
Organism Escherichia coli strain JP538

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag R5G_RS10235 Protein ID WP_000415584.1
Coordinates 2055314..2055610 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag R5G_RS10230 Protein ID WP_000650107.1
Coordinates 2054917..2055312 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
R5G_RS10220 (2050781) 2050781..2053039 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
R5G_RS10225 (2053177) 2053177..2054784 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
R5G_RS10230 (2054917) 2054917..2055312 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
R5G_RS10235 (2055314) 2055314..2055610 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
R5G_RS10240 (2055815) 2055815..2056297 - 483 WP_000183505.1 GyrI-like domain-containing protein -
R5G_RS10245 (2056350) 2056350..2056742 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
R5G_RS10250 (2056894) 2056894..2057553 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
R5G_RS10255 (2057550) 2057550..2058899 + 1350 WP_032231458.1 quorum sensing histidine kinase QseC -
R5G_RS10260 (2058945) 2058945..2059277 - 333 WP_000917684.1 DUF2645 family protein -
R5G_RS10265 (2059596) 2059596..2060177 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
R5G_RS10270 (2060208) 2060208..2060522 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T40044 WP_000415584.1 NZ_AP025180:c2055610-2055314 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T40044 NZ_AP025180:c2055610-2055314 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT40044 WP_000650107.1 NZ_AP025180:c2055312-2054917 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT40044 NZ_AP025180:c2055312-2054917 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References