Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 116924..117295 | Replicon | chromosome |
| Accession | NZ_AP025180 | ||
| Organism | Escherichia coli strain JP538 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A0D6ZRD3 |
| Locus tag | R5G_RS00640 | Protein ID | WP_001443846.1 |
| Coordinates | 117146..117295 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 116924..117102 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| R5G_RS25670 (112676) | 112676..112849 | + | 174 | WP_001296046.1 | protein YnaL | - |
| R5G_RS00615 (112879) | 112879..114252 | + | 1374 | WP_000123745.1 | ATP-dependent RNA helicase DbpA | - |
| R5G_RS00620 (114381) | 114381..115316 | - | 936 | WP_000662472.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| R5G_RS00625 (115368) | 115368..116603 | - | 1236 | WP_000040839.1 | site-specific integrase | - |
| R5G_RS00630 (116605) | 116605..116820 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (116924) | 116924..117102 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (116924) | 116924..117102 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (116924) | 116924..117102 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (116924) | 116924..117102 | + | 179 | NuclAT_0 | - | Antitoxin |
| R5G_RS00635 (116920) | 116920..117108 | - | 189 | WP_001302840.1 | DUF1187 family protein | - |
| R5G_RS00640 (117146) | 117146..117295 | - | 150 | WP_001443846.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| R5G_RS00645 (117351) | 117351..118160 | - | 810 | WP_000166313.1 | recombination protein RecT | - |
| R5G_RS00650 (118153) | 118153..120753 | - | 2601 | WP_000105140.1 | exodeoxyribonuclease VIII | - |
| R5G_RS00655 (120855) | 120855..121130 | - | 276 | WP_000632297.1 | protein RacC | - |
| R5G_RS00660 (121205) | 121205..121375 | - | 171 | WP_001352098.1 | YdaE family protein | - |
| R5G_RS00665 (121375) | 121375..121596 | - | 222 | WP_000560223.1 | killing protein KilR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 93474..164064 | 70590 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5383.12 Da Isoelectric Point: 8.3398
>T40026 WP_001443846.1 NZ_AP025180:c117295-117146 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
Download Length: 150 bp
>T40026 NZ_AP025180:c117295-117146 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
Antitoxin
Download Length: 179 bp
>AT40026 NZ_AP025180:116924-117102 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
