Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2503104..2503627 Replicon chromosome
Accession NZ_AP025177
Organism Staphylococcus aureus strain TPS6281

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag CC22TP_RS12485 Protein ID WP_000074048.1
Coordinates 2503104..2503370 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag CC22TP_RS12490 Protein ID WP_000587616.1
Coordinates 2503370..2503627 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CC22TP_RS12465 (2498315) 2498315..2499502 - 1188 WP_000026196.1 MFS transporter -
CC22TP_RS12470 (2499896) 2499896..2500672 - 777 WP_000072155.1 iron export ABC transporter permease subunit FetB -
CC22TP_RS12475 (2500665) 2500665..2501327 - 663 WP_000923509.1 ATP-binding cassette domain-containing protein -
CC22TP_RS12480 (2501673) 2501673..2502749 - 1077 WP_001076687.1 M42 family metallopeptidase -
CC22TP_RS12485 (2503104) 2503104..2503370 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
CC22TP_RS12490 (2503370) 2503370..2503627 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CC22TP_RS12495 (2503986) 2503986..2504441 + 456 WP_000732082.1 DUF1307 domain-containing protein -
CC22TP_RS12500 (2504609) 2504609..2506186 - 1578 WP_000143486.1 FMN-binding glutamate synthase family protein -
CC22TP_RS12505 (2506381) 2506381..2507130 + 750 WP_000072439.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T40018 WP_000074048.1 NZ_AP025177:c2503370-2503104 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T40018 NZ_AP025177:c2503370-2503104 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT40018 WP_000587616.1 NZ_AP025177:c2503627-2503370 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT40018 NZ_AP025177:c2503627-2503370 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References