Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2471810..2471994 Replicon chromosome
Accession NZ_AP025177
Organism Staphylococcus aureus strain TPS6281

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag CC22TP_RS12345 Protein ID WP_000482647.1
Coordinates 2471887..2471994 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2471810..2471870 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CC22TP_RS12335 2467606..2469339 - 1734 WP_000486501.1 ABC transporter ATP-binding protein -
CC22TP_RS12340 2469364..2471127 - 1764 WP_001064811.1 ATP-binding cassette domain-containing protein -
- 2471810..2471870 + 61 - - Antitoxin
CC22TP_RS12345 2471887..2471994 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
CC22TP_RS12350 2472127..2472513 - 387 WP_000779356.1 flippase GtxA -
CC22TP_RS12355 2472781..2473923 + 1143 WP_001176863.1 glycerate kinase -
CC22TP_RS12360 2473983..2474642 + 660 WP_000831298.1 membrane protein -
CC22TP_RS12365 2474821..2476032 + 1212 WP_001191976.1 multidrug effflux MFS transporter -
CC22TP_RS12370 2476155..2476628 - 474 WP_000456498.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T40016 WP_000482647.1 NZ_AP025177:c2471994-2471887 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T40016 NZ_AP025177:c2471994-2471887 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT40016 NZ_AP025177:2471810-2471870 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References