Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2445097..2445614 Replicon chromosome
Accession NZ_AP025177
Organism Staphylococcus aureus strain TPS6281

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CC22TP_RS12205 Protein ID WP_000113261.1
Coordinates 2445097..2445363 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CC22TP_RS12210 Protein ID WP_000584499.1
Coordinates 2445363..2445614 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CC22TP_RS12175 (2440534) 2440534..2441070 - 537 WP_000169319.1 GNAT family N-acetyltransferase -
CC22TP_RS12180 (2441304) 2441304..2442128 - 825 WP_000594640.1 formate/nitrite transporter family protein -
CC22TP_RS12185 (2442331) 2442331..2442513 - 183 WP_000250735.1 hypothetical protein -
CC22TP_RS12190 (2442600) 2442600..2443067 - 468 WP_000153345.1 SRPBCC domain-containing protein -
CC22TP_RS12195 (2443253) 2443253..2444803 - 1551 WP_000727760.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CC22TP_RS12200 (2444991) 2444991..2445062 - 72 WP_223200558.1 hypothetical protein -
CC22TP_RS12205 (2445097) 2445097..2445363 - 267 WP_000113261.1 Txe/YoeB family addiction module toxin Toxin
CC22TP_RS12210 (2445363) 2445363..2445614 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CC22TP_RS12215 (2445777) 2445777..2445878 - 102 Protein_2364 hypothetical protein -
CC22TP_RS12220 (2445885) 2445885..2446484 - 600 WP_103204748.1 DsbA family protein -
CC22TP_RS12225 (2446503) 2446503..2446865 - 363 WP_000819843.1 DUF4467 domain-containing protein -
CC22TP_RS12230 (2447120) 2447120..2448370 + 1251 WP_001012231.1 FemA/FemB family glycyltransferase FmhA -
CC22TP_RS12235 (2448455) 2448455..2449186 - 732 WP_000615455.1 amino acid ABC transporter ATP-binding protein -
CC22TP_RS12240 (2449183) 2449183..2449902 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10452.02 Da        Isoelectric Point: 10.0373

>T40015 WP_000113261.1 NZ_AP025177:c2445363-2445097 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY

Download         Length: 267 bp

>T40015 NZ_AP025177:c2445363-2445097 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAAGCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT40015 WP_000584499.1 NZ_AP025177:c2445614-2445363 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT40015 NZ_AP025177:c2445614-2445363 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAGCACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References