Detailed information of TA system TA040007

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2009253..2009560
• Replicon: chromosome
• Accession: NZ_AP025177
• Organism: Staphylococcus aureus strain TPS6281

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: CC22TP_RS09865
• Protein ID: WP_072357969.1
• Coordinates: 2009384..2009560 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2009253..2009392 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CC22TP_RS09825 (2004596)	2004596..2004856	+	261	WP_001791826.1	hypothetical protein	-
CC22TP_RS09830 (2004909)	2004909..2005259	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
CC22TP_RS09835 (2005942)	2005942..2006391	+	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
CC22TP_RS09840 (2006484)	2006484..2006818	-	335	Protein_1902	SH3 domain-containing protein	-
CC22TP_RS09845 (2007469)	2007469..2007960	-	492	WP_000920041.1	staphylokinase	-
CC22TP_RS09850 (2008151)	2008151..2008906	-	756	WP_000861038.1	CHAP domain-containing protein	-
CC22TP_RS09855 (2008918)	2008918..2009172	-	255	WP_000611512.1	phage holin	-
CC22TP_RS09860 (2009224)	2009224..2009331	+	108	WP_031762631.1	hypothetical protein	-
- (2009253)	2009253..2009392	+	140	NuclAT_0	-	Antitoxin
- (2009253)	2009253..2009392	+	140	NuclAT_0	-	Antitoxin
- (2009253)	2009253..2009392	+	140	NuclAT_0	-	Antitoxin
- (2009253)	2009253..2009392	+	140	NuclAT_0	-	Antitoxin
CC22TP_RS09865 (2009384)	2009384..2009560	-	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
CC22TP_RS09870 (2009712)	2009712..2010008	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CC22TP_RS09875 (2010066)	2010066..2010353	-	288	WP_001040261.1	hypothetical protein	-
CC22TP_RS09880 (2010400)	2010400..2010552	-	153	WP_001153681.1	hypothetical protein	-
CC22TP_RS09885 (2010542)	2010542..2014327	-	3786	WP_229346810.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2004909..2058902	53993

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T40007 WP_072357969.1 NZ_AP025177:c2009560-2009384 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T40007 NZ_AP025177:c2009560-2009384 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT40007 NZ_AP025177:2009253-2009392 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin