Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1854675..1854855 Replicon chromosome
Accession NZ_AP025177
Organism Staphylococcus aureus strain TPS6281

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag CC22TP_RS08895 Protein ID WP_001801861.1
Coordinates 1854675..1854770 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1854798..1854855 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CC22TP_RS08865 1850131..1850771 - 641 Protein_1745 ImmA/IrrE family metallo-endopeptidase -
CC22TP_RS08870 1851179..1851946 - 768 WP_001095317.1 IS21-like element helper ATPase IstB -
CC22TP_RS08875 1851958..1853193 - 1236 WP_001215400.1 IS21 family transposase -
CC22TP_RS08880 1853291..1853452 - 162 WP_217654656.1 hypothetical protein -
CC22TP_RS08885 1853463..1853846 - 384 WP_000070809.1 hypothetical protein -
CC22TP_RS08890 1854028..1854252 - 225 WP_001805677.1 IS3 family transposase -
CC22TP_RS08895 1854675..1854770 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1854798..1854855 - 58 - - Antitoxin
CC22TP_RS08900 1854893..1854994 + 102 WP_001791232.1 hypothetical protein -
CC22TP_RS08905 1854972..1855144 - 173 Protein_1753 transposase -
CC22TP_RS08910 1855338..1855715 - 378 WP_001036002.1 DUF1433 domain-containing protein -
CC22TP_RS08915 1855921..1856361 - 441 WP_000759947.1 DUF1433 domain-containing protein -
CC22TP_RS08920 1856406..1858019 + 1614 WP_000926708.1 lipase -
CC22TP_RS08925 1858034..1858333 + 300 WP_000095392.1 WXG100 family type VII secretion target -
CC22TP_RS08930 1858648..1859829 - 1182 WP_000162901.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk 1825323..1871083 45760


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T40004 WP_001801861.1 NZ_AP025177:1854675-1854770 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T40004 NZ_AP025177:1854675-1854770 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT40004 NZ_AP025177:c1854855-1854798 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References