Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2545790..2546313 Replicon chromosome
Accession NZ_AP025176
Organism Staphylococcus aureus strain TPS5614

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag LPC25_RS12750 Protein ID WP_000074048.1
Coordinates 2545790..2546056 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag LPC25_RS12755 Protein ID WP_000587616.1
Coordinates 2546056..2546313 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC25_RS12730 (2541001) 2541001..2542188 - 1188 WP_000026196.1 MFS transporter -
LPC25_RS12735 (2542582) 2542582..2543358 - 777 WP_000072155.1 iron export ABC transporter permease subunit FetB -
LPC25_RS12740 (2543351) 2543351..2544013 - 663 WP_000923509.1 ATP-binding cassette domain-containing protein -
LPC25_RS12745 (2544359) 2544359..2545435 - 1077 WP_001076687.1 M42 family metallopeptidase -
LPC25_RS12750 (2545790) 2545790..2546056 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
LPC25_RS12755 (2546056) 2546056..2546313 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LPC25_RS12760 (2546672) 2546672..2547127 + 456 WP_000732082.1 DUF1307 domain-containing protein -
LPC25_RS12765 (2547295) 2547295..2548872 - 1578 WP_000143486.1 FMN-binding glutamate synthase family protein -
LPC25_RS12770 (2549067) 2549067..2549816 + 750 WP_000072439.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T40002 WP_000074048.1 NZ_AP025176:c2546056-2545790 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T40002 NZ_AP025176:c2546056-2545790 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT40002 WP_000587616.1 NZ_AP025176:c2546313-2546056 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT40002 NZ_AP025176:c2546313-2546056 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References