Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2514495..2514679 Replicon chromosome
Accession NZ_AP025176
Organism Staphylococcus aureus strain TPS5614

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag LPC25_RS12610 Protein ID WP_000482647.1
Coordinates 2514572..2514679 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2514495..2514555 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC25_RS12600 2510347..2512080 - 1734 WP_000486501.1 ABC transporter ATP-binding protein -
LPC25_RS12605 2512105..2513868 - 1764 WP_001064812.1 ABC transporter ATP-binding protein -
- 2514495..2514555 + 61 - - Antitoxin
LPC25_RS12610 2514572..2514679 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
LPC25_RS12615 2514813..2515199 - 387 WP_000779356.1 flippase GtxA -
LPC25_RS12620 2515467..2516609 + 1143 WP_001176863.1 glycerate kinase -
LPC25_RS12625 2516669..2517328 + 660 WP_000831298.1 membrane protein -
LPC25_RS12630 2517507..2518718 + 1212 WP_001191976.1 multidrug effflux MFS transporter -
LPC25_RS12635 2518841..2519314 - 474 WP_000456498.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T40000 WP_000482647.1 NZ_AP025176:c2514679-2514572 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T40000 NZ_AP025176:c2514679-2514572 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT40000 NZ_AP025176:2514495-2514555 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References