Detailed information of TA system TA039991

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2055706..2056013
• Replicon: chromosome
• Accession: NZ_AP025176
• Organism: Staphylococcus aureus strain TPS5614

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: LPC25_RS10160
• Protein ID: WP_072357969.1
• Coordinates: 2055837..2056013 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2055706..2055845 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPC25_RS10120 (2051050)	2051050..2051310	+	261	WP_001791826.1	hypothetical protein	-
LPC25_RS10125 (2051363)	2051363..2051713	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
LPC25_RS10130 (2052395)	2052395..2052844	+	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
LPC25_RS10135 (2052937)	2052937..2053271	-	335	Protein_1963	SH3 domain-containing protein	-
LPC25_RS10140 (2053922)	2053922..2054413	-	492	WP_000920041.1	staphylokinase	-
LPC25_RS10145 (2054604)	2054604..2055359	-	756	WP_000861038.1	CHAP domain-containing protein	-
LPC25_RS10150 (2055371)	2055371..2055625	-	255	WP_000611512.1	phage holin	-
LPC25_RS10155 (2055677)	2055677..2055784	+	108	WP_031762631.1	hypothetical protein	-
- (2055706)	2055706..2055845	+	140	NuclAT_0	-	Antitoxin
- (2055706)	2055706..2055845	+	140	NuclAT_0	-	Antitoxin
- (2055706)	2055706..2055845	+	140	NuclAT_0	-	Antitoxin
- (2055706)	2055706..2055845	+	140	NuclAT_0	-	Antitoxin
LPC25_RS10160 (2055837)	2055837..2056013	-	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
LPC25_RS10165 (2056165)	2056165..2056461	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
LPC25_RS10170 (2056519)	2056519..2056806	-	288	WP_001040261.1	hypothetical protein	-
LPC25_RS10175 (2056853)	2056853..2057005	-	153	WP_001153681.1	hypothetical protein	-
LPC25_RS10180 (2056995)	2056995..2060780	-	3786	WP_000582148.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2051363..2105272	53909

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T39991 WP_072357969.1 NZ_AP025176:c2056013-2055837 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T39991 NZ_AP025176:c2056013-2055837 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT39991 NZ_AP025176:2055706-2055845 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin