Detailed information of TA system TA039988

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1898460..1898640
• Replicon: chromosome
• Accession: NZ_AP025176
• Organism: Staphylococcus aureus strain TPS5614

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: LPC25_RS09170
• Protein ID: WP_001801861.1
• Coordinates: 1898460..1898555 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1898583..1898640 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPC25_RS09135	1894241..1894867	+	627	WP_000669029.1	hypothetical protein	-
LPC25_RS09140	1894908..1895249	+	342	WP_000627535.1	DUF3969 family protein	-
LPC25_RS09145	1895350..1895922	+	573	WP_000414208.1	hypothetical protein	-
LPC25_RS09150	1896119..1896759	-	641	Protein_1805	ImmA/IrrE family metallo-endopeptidase	-
LPC25_RS09155	1897061..1897237	-	177	WP_000375476.1	hypothetical protein	-
LPC25_RS09160	1897248..1897631	-	384	WP_000070809.1	hypothetical protein	-
LPC25_RS09165	1897813..1898037	-	225	WP_001805677.1	IS3 family transposase	-
LPC25_RS09170	1898460..1898555	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1898583..1898640	-	58	-	-	Antitoxin
LPC25_RS09175	1898678..1898779	+	102	WP_001791232.1	hypothetical protein	-
LPC25_RS09180	1898757..1898929	-	173	Protein_1811	transposase	-
LPC25_RS09185	1899123..1899500	-	378	WP_001036002.1	DUF1433 domain-containing protein	-
LPC25_RS09190	1899706..1900146	-	441	WP_000759947.1	DUF1433 domain-containing protein	-
LPC25_RS09195	1900191..1901804	+	1614	WP_000926708.1	lipase	-
LPC25_RS09200	1901819..1902118	+	300	WP_000095392.1	WXG100 family type VII secretion target	-
LPC25_RS09205	1902433..1903614	-	1182	WP_000162901.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk	1891682..1914868	23186

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T39988 WP_001801861.1 NZ_AP025176:1898460-1898555 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T39988 NZ_AP025176:1898460-1898555 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT39988 NZ_AP025176:c1898640-1898583 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin