Detailed information of TA system TA039979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 4250650..4251304
• Replicon: chromosome
• Accession: NZ_AP025169
• Organism: Pseudomonas sp. CYM-20-01

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A223VZF1
• Locus tag: M2497_RS19025
• Protein ID: WP_071493394.1
• Coordinates: 4250650..4251000 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: M2497_RS19030
• Protein ID: WP_248482319.1
• Coordinates: 4250990..4251304 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2497_RS19015 (cym2001_37550)	4247408..4248940	+	1533	WP_010209575.1	NADH-quinone oxidoreductase subunit M	-
M2497_RS19020 (cym2001_37560)	4248948..4250411	+	1464	WP_058425023.1	NADH-quinone oxidoreductase subunit NuoN	-
M2497_RS19025 (cym2001_37570)	4250650..4251000	+	351	WP_071493394.1	toxin	Toxin
M2497_RS19030 (cym2001_37580)	4250990..4251304	+	315	WP_248482319.1	transcriptional regulator	Antitoxin
M2497_RS19035 (cym2001_37590)	4251364..4252116	-	753	WP_058425025.1	outer membrane beta-barrel protein	-
M2497_RS19040 (cym2001_37600)	4252244..4253077	-	834	WP_248482321.1	arylamine N-acetyltransferase	-
M2497_RS19045 (cym2001_37610)	4253198..4253434	+	237	WP_058425027.1	hypothetical protein	-
M2497_RS19050 (cym2001_37620)	4253649..4254632	+	984	WP_248482323.1	DUF1852 domain-containing protein	-
M2497_RS19055 (cym2001_37630)	4254660..4255691	+	1032	WP_248482325.1	methionine synthase	-
M2497_RS19060 (cym2001_37640)	4255767..4256276	+	510	WP_248482326.1	flavin reductase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13804.70 Da
• Isoelectric Point: 9.3833

>T39979 WP_071493394.1 NZ_AP025169:4250650-4251000 [Pseudomonas sp. CYM-20-01]
MDALFIELPAFERHRKDYLSDELFQGFQQELMKNPEAGDVIEGTGGLRKVRFIDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEQDDLTPQHKKALKHMLDREIKARTHHET

Nucleotide

• Length: 351 bp

>T39979 NZ_AP025169:4250650-4251000 [Pseudomonas sp. CYM-20-01]
ATGGATGCTCTATTTATCGAACTGCCGGCCTTCGAGCGGCATCGCAAGGACTATCTGAGTGACGAGCTTTTCCAGGGTTT
TCAACAAGAGTTGATGAAGAACCCGGAAGCAGGAGATGTGATCGAGGGAACAGGCGGACTGCGCAAAGTTCGCTTCATCG
ATGAGCGACGCAACAAAGGCAAGCGCGGTGGCCTGCGGGTCATTTACTACTGGTGGTCGGGCGGCACGCAATTCTGGCTG
TTCACCCTGTACGGCAAGCACGAACAGGATGACCTGACACCACAGCACAAAAAAGCCCTAAAACACATGCTGGACAGGGA
AATCAAAGCGAGAACACATCATGAAACGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11772.52 Da
• Isoelectric Point: 9.9898

>AT39979 WP_248482319.1 NZ_AP025169:4250990-4251304 [Pseudomonas sp. CYM-20-01]
MKREIFSELVEGFDALADERQGKVTLRTHKVHLNQLEPLTAEEVVAVRQQLNLSRSVFAMYLRTNTRTLENWEQGRAKPN
AQAATLIRLVARFPETVAQLAALG

Nucleotide

• Length: 315 bp

>AT39979 NZ_AP025169:4250990-4251304 [Pseudomonas sp. CYM-20-01]
ATGAAACGTGAAATCTTTTCCGAACTGGTCGAAGGCTTCGACGCCCTGGCAGACGAACGCCAAGGCAAAGTCACCCTGCG
AACCCATAAGGTTCATCTCAATCAACTGGAGCCGCTTACCGCCGAGGAGGTGGTGGCCGTGCGCCAGCAACTCAACCTCT
CCCGGTCGGTGTTCGCCATGTACCTGCGCACCAACACCCGTACCCTGGAAAACTGGGAACAAGGTCGGGCCAAGCCAAAT
GCCCAGGCTGCCACGCTGATTCGCCTGGTGGCACGTTTTCCTGAGACCGTGGCGCAACTTGCCGCTTTGGGTTGA

Structures

Toxin

• AlphaFold DB: A0A223VZF1