Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 1378734..1379566 | Replicon | chromosome |
| Accession | NZ_AP025160 | ||
| Organism | Acidithiobacillus ferrooxidans strain NFP31 | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | B7J9L0 |
| Locus tag | ANFP_RS07145 | Protein ID | WP_009569577.1 |
| Coordinates | 1378734..1379240 (-) | Length | 169 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | B7J9L1 |
| Locus tag | ANFP_RS07150 | Protein ID | WP_009569578.1 |
| Coordinates | 1379237..1379566 (-) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ANFP_RS07115 (ANFP_14300) | 1373742..1374131 | + | 390 | WP_009565421.1 | holo-ACP synthase | - |
| ANFP_RS07120 (ANFP_14310) | 1374135..1375457 | + | 1323 | WP_012607056.1 | UDP-glucose/GDP-mannose dehydrogenase family protein | - |
| ANFP_RS07125 (ANFP_14320) | 1375438..1376409 | + | 972 | WP_049759457.1 | D-glycero-beta-D-manno-heptose-7-phosphate kinase | - |
| ANFP_RS07130 (ANFP_14330) | 1376399..1377181 | + | 783 | WP_012607057.1 | ATP-binding protein | - |
| ANFP_RS07135 (ANFP_14340) | 1377174..1378016 | + | 843 | WP_012536503.1 | Hsp33 family molecular chaperone HslO | - |
| ANFP_RS07145 (ANFP_14350) | 1378734..1379240 | - | 507 | WP_009569577.1 | type II toxin-antitoxin system YhaV family toxin | Toxin |
| ANFP_RS07150 (ANFP_14360) | 1379237..1379566 | - | 330 | WP_009569578.1 | type II toxin-antitoxin system PrlF family antitoxin | Antitoxin |
| ANFP_RS07155 | 1379853..1379996 | + | 144 | WP_009569579.1 | hypothetical protein | - |
| ANFP_RS07160 (ANFP_14370) | 1380023..1380289 | - | 267 | WP_012536504.1 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
| ANFP_RS07165 (ANFP_14380) | 1380634..1381128 | - | 495 | WP_009565062.1 | GNAT family N-acetyltransferase | - |
| ANFP_RS07170 (ANFP_14390) | 1381125..1381397 | - | 273 | WP_012536505.1 | DUF1778 domain-containing protein | - |
| ANFP_RS07175 (ANFP_14400) | 1381478..1381690 | - | 213 | WP_009562915.1 | hypothetical protein | - |
| ANFP_RS07180 (ANFP_14410) | 1381858..1382070 | - | 213 | WP_041645801.1 | hypothetical protein | - |
| ANFP_RS07185 (ANFP_14430) | 1382474..1383295 | - | 822 | WP_012536506.1 | UDP-2,3-diacylglucosamine diphosphatase | - |
| ANFP_RS07190 (ANFP_14440) | 1383536..1383781 | + | 246 | WP_009568482.1 | DUF2934 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 169 a.a. Molecular weight: 19373.17 Da Isoelectric Point: 9.9366
>T39961 WP_009569577.1 NZ_AP025160:c1379240-1378734 [Acidithiobacillus ferrooxidans]
MSSSKLAPLVIHGWTVFAHPLFLAHIETLAQQVEAFKKKDPVGYVKKNANKRLAAIIKLAFDAIPQDPTRPEYRQGNTLG
EDHKHWFRAKFFQQYRLFFRYHAPSKVIVLAWVNDEDTKRAYESSDDAYRVFRKMLESGRPPDDWNQLLAEACAEGQRLQ
RFAAGIAP
MSSSKLAPLVIHGWTVFAHPLFLAHIETLAQQVEAFKKKDPVGYVKKNANKRLAAIIKLAFDAIPQDPTRPEYRQGNTLG
EDHKHWFRAKFFQQYRLFFRYHAPSKVIVLAWVNDEDTKRAYESSDDAYRVFRKMLESGRPPDDWNQLLAEACAEGQRLQ
RFAAGIAP
Download Length: 507 bp
>T39961 NZ_AP025160:c1379240-1378734 [Acidithiobacillus ferrooxidans]
ATGAGCTCGAGCAAGCTCGCGCCCTTGGTCATTCATGGCTGGACGGTTTTTGCCCACCCGCTATTCCTCGCGCATATTGA
GACCTTGGCCCAGCAGGTCGAGGCCTTCAAGAAAAAGGATCCCGTCGGATACGTGAAAAAGAACGCCAATAAGCGACTGG
CGGCGATCATCAAACTGGCGTTCGACGCCATCCCGCAAGACCCGACACGGCCAGAGTACCGTCAAGGCAACACCCTCGGT
GAAGATCACAAGCACTGGTTCCGCGCCAAGTTTTTCCAGCAATACCGGCTGTTCTTCCGCTACCACGCGCCGAGCAAGGT
GATCGTGCTCGCCTGGGTCAATGACGAGGACACCAAGCGCGCCTATGAGAGCAGTGACGACGCCTATCGGGTGTTCCGAA
AGATGCTGGAAAGCGGCCGTCCTCCGGATGACTGGAACCAGTTGCTGGCCGAGGCATGCGCCGAGGGGCAGCGACTACAG
CGATTCGCTGCTGGCATTGCACCGTAA
ATGAGCTCGAGCAAGCTCGCGCCCTTGGTCATTCATGGCTGGACGGTTTTTGCCCACCCGCTATTCCTCGCGCATATTGA
GACCTTGGCCCAGCAGGTCGAGGCCTTCAAGAAAAAGGATCCCGTCGGATACGTGAAAAAGAACGCCAATAAGCGACTGG
CGGCGATCATCAAACTGGCGTTCGACGCCATCCCGCAAGACCCGACACGGCCAGAGTACCGTCAAGGCAACACCCTCGGT
GAAGATCACAAGCACTGGTTCCGCGCCAAGTTTTTCCAGCAATACCGGCTGTTCTTCCGCTACCACGCGCCGAGCAAGGT
GATCGTGCTCGCCTGGGTCAATGACGAGGACACCAAGCGCGCCTATGAGAGCAGTGACGACGCCTATCGGGTGTTCCGAA
AGATGCTGGAAAGCGGCCGTCCTCCGGATGACTGGAACCAGTTGCTGGCCGAGGCATGCGCCGAGGGGCAGCGACTACAG
CGATTCGCTGCTGGCATTGCACCGTAA
Antitoxin
Download Length: 110 a.a. Molecular weight: 12107.54 Da Isoelectric Point: 4.3141
>AT39961 WP_009569578.1 NZ_AP025160:c1379566-1379237 [Acidithiobacillus ferrooxidans]
MAATLEVESTLTDRYQTTVPETVRRALRLGKRDKIHYTIRPGGEVVLTRAEDSEEDDPVLGQFLGFLARDIATHPERLQA
IDVSFVQRLQSLTGGIEVDLDAPLSADDE
MAATLEVESTLTDRYQTTVPETVRRALRLGKRDKIHYTIRPGGEVVLTRAEDSEEDDPVLGQFLGFLARDIATHPERLQA
IDVSFVQRLQSLTGGIEVDLDAPLSADDE
Download Length: 330 bp
>AT39961 NZ_AP025160:c1379566-1379237 [Acidithiobacillus ferrooxidans]
ATGGCTGCCACCCTCGAAGTCGAATCCACGCTGACTGACCGCTACCAAACCACGGTGCCGGAGACCGTCCGCCGGGCCCT
CCGGCTGGGCAAGCGCGACAAGATCCACTACACCATCCGCCCCGGTGGCGAGGTCGTGCTGACGCGCGCCGAGGACTCCG
AGGAAGACGATCCGGTGCTCGGTCAGTTCCTGGGCTTCCTGGCCCGCGACATCGCCACGCATCCAGAGCGCCTGCAGGCC
ATCGATGTCAGCTTCGTGCAGCGCCTCCAATCGCTGACCGGCGGCATCGAAGTCGATCTCGATGCCCCCTTGTCTGCGGA
CGATGAATGA
ATGGCTGCCACCCTCGAAGTCGAATCCACGCTGACTGACCGCTACCAAACCACGGTGCCGGAGACCGTCCGCCGGGCCCT
CCGGCTGGGCAAGCGCGACAAGATCCACTACACCATCCGCCCCGGTGGCGAGGTCGTGCTGACGCGCGCCGAGGACTCCG
AGGAAGACGATCCGGTGCTCGGTCAGTTCCTGGGCTTCCTGGCCCGCGACATCGCCACGCATCCAGAGCGCCTGCAGGCC
ATCGATGTCAGCTTCGTGCAGCGCCTCCAATCGCTGACCGGCGGCATCGAAGTCGATCTCGATGCCCCCTTGTCTGCGGA
CGATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|