Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 87242..87850 Replicon chromosome
Accession NZ_AP025160
Organism Acidithiobacillus ferrooxidans strain NFP31

Toxin (Protein)


Gene name higB Uniprot ID A0A2W1K1W3
Locus tag ANFP_RS00440 Protein ID WP_012535782.1
Coordinates 87242..87517 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag ANFP_RS00445 Protein ID WP_009566298.1
Coordinates 87533..87850 (+) Length 106 a.a.

Genomic Context

ANFP_RS00405ANFP_RS00410ANFP_RS00415ANFP_RS00425ANFP_RS00430ANFP_RS00435ANFP_RS00440ANFP_RS00445ANFP_RS00450ANFP_RS00455ANFP_RS16555ANFP_RS00460ANFP_RS00465ANFP_RS00470ANFP_RS00475ANFP_RS00480
Location: 83020..84060 (1041 bp)
Type: Others
Protein ID: WP_012535779.1
Location: 84128..85054 (927 bp)
Type: Others
Protein ID: WP_012535780.1
Location: 85047..85415 (369 bp)
Type: Others
Protein ID: WP_012535781.1
Location: 86155..86376 (222 bp)
Type: Others
Protein ID: WP_009566302.1
Location: 86376..86789 (414 bp)
Type: Others
Protein ID: WP_009566301.1
Location: 86786..87076 (291 bp)
Type: Others
Protein ID: WP_009566300.1
Location: 87242..87517 (276 bp)
Type: Toxin
Protein ID: WP_012535782.1
Location: 87533..87850 (318 bp)
Type: Antitoxin
Protein ID: WP_009566298.1
Location: 87865..88044 (180 bp)
Type: Others
Protein ID: WP_009566297.1
Location: 88464..89627 (1164 bp)
Type: Others
Protein ID: WP_009566294.1
Location: 88144..88272 (129 bp)
Type: Others
Protein ID: WP_257246670.1
Location: 89924..90190 (267 bp)
Type: Others
Protein ID: WP_196491178.1
Location: 90187..90429 (243 bp)
Type: Others
Protein ID: WP_012535785.1
Location: 90513..90686 (174 bp)
Type: Others
Protein ID: WP_009562770.1
Location: 90797..91225 (429 bp)
Type: Others
Protein ID: WP_009562768.1
Location: 91228..91659 (432 bp)
Type: Others
Protein ID: WP_009562767.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ANFP_RS00405 (ANFP_00830)83020..84060+1041WP_012535779.1glycosyltransferase family 1 protein-
ANFP_RS00410 (ANFP_00840)84128..85054+927WP_012535780.1glycosyltransferase-
ANFP_RS00415 (ANFP_00850)85047..85415+369WP_012535781.1glycosyltransferase-
ANFP_RS00425 (ANFP_00860)86155..86376+222WP_009566302.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ANFP_RS00430 (ANFP_00870)86376..86789+414WP_009566301.1type II toxin-antitoxin system VapC family toxin-
ANFP_RS00435 (ANFP_00880)86786..87076+291WP_009566300.1hypothetical protein-
ANFP_RS00440 (ANFP_00890)87242..87517+276WP_012535782.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ANFP_RS00445 (ANFP_00900)87533..87850+318WP_009566298.1HigA family addiction module antitoxinAntitoxin
ANFP_RS0045087865..88044+180WP_009566297.1HNH endonuclease-
ANFP_RS16555 (ANFP_00920)88144..88272-129WP_257246670.1hypothetical protein-
ANFP_RS00455 (ANFP_00930)88464..89627+1164WP_009566294.1Fic family protein-
ANFP_RS00460 (ANFP_00940)89924..90190-267WP_196491178.1hypothetical protein-
ANFP_RS00465 (ANFP_00950)90187..90429-243WP_012535785.1type II toxin-antitoxin system prevent-host-death family antitoxin-
ANFP_RS00470 (ANFP_00960)90513..90686-174WP_009562770.1PCP reductase family protein-
ANFP_RS00475 (ANFP_00970)90797..91225-429WP_009562768.1hypothetical protein-
ANFP_RS00480 (ANFP_00980)91228..91659-432WP_009562767.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10433.84 Da        Isoelectric Point: 7.9070

>T39955 WP_012535782.1 NZ_AP025160:87242-87517 [Acidithiobacillus ferrooxidans]
MIRSFVHKGLKQVFETGQSAKVGADLVTRCKRRLDAINAATSPEELNVPGFDFHALEGKPKRYTVHVNGPYCITFEWREG
DAWRIDLENYH

Download         Length: 276 bp

>T39955 NZ_AP025160:87242-87517 [Acidithiobacillus ferrooxidans]
TTGATACGAAGTTTTGTGCATAAGGGCCTCAAGCAGGTTTTCGAAACAGGTCAATCGGCGAAAGTCGGTGCGGATTTGGT
AACCCGCTGCAAGCGCAGGCTCGATGCCATAAACGCTGCGACATCCCCGGAGGAGTTGAACGTGCCGGGTTTCGACTTCC
ATGCTTTGGAGGGGAAACCGAAGCGGTACACGGTTCATGTGAATGGACCCTATTGCATCACCTTCGAGTGGCGTGAAGGA
GATGCCTGGCGCATTGATCTGGAGAATTACCATTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11756.54 Da        Isoelectric Point: 5.6631

>AT39955 WP_009566298.1 NZ_AP025160:87533-87850 [Acidithiobacillus ferrooxidans]
MDEMTVEQVDRIPTHPGEILREEVLPALDISVAEFARGLRVSRQTVHGILSERKGITPEMALRIGKYLGNGPGIWLRMQQ
AYDLTVAERRLAEELAAIHKPEQAA

Download         Length: 318 bp

>AT39955 NZ_AP025160:87533-87850 [Acidithiobacillus ferrooxidans]
ATGGACGAAATGACCGTTGAGCAAGTGGATCGGATACCGACGCATCCTGGCGAGATATTGCGGGAAGAGGTACTGCCCGC
ACTGGATATCTCTGTAGCAGAGTTTGCCCGTGGCCTGCGGGTCTCGCGCCAGACCGTTCACGGCATCCTGTCTGAGCGCA
AGGGCATCACCCCGGAGATGGCCTTGCGTATCGGCAAATATCTGGGTAACGGGCCGGGGATATGGCTACGCATGCAGCAG
GCTTACGATTTGACCGTTGCAGAACGTCGGTTGGCCGAAGAACTGGCGGCCATTCACAAGCCCGAGCAGGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2W1K1W3

Antitoxin

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Source
ID
Structure
No matching records found

References