Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 3557252..3557826 | Replicon | chromosome |
| Accession | NZ_AP025028 | ||
| Organism | Leptospira kobayashii strain E30 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | DI077_RS16105 | Protein ID | WP_109022133.1 |
| Coordinates | 3557252..3557530 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | DI077_RS16110 | Protein ID | WP_109021318.1 |
| Coordinates | 3557530..3557826 (+) | Length | 99 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DI077_RS16075 (LPTSP3_g31740) | 3552992..3553867 | + | 876 | WP_109022525.1 | putative phage abortive infection protein | - |
| DI077_RS16080 (LPTSP3_g31750) | 3554071..3555408 | + | 1338 | WP_109022555.1 | hypothetical protein | - |
| DI077_RS16085 (LPTSP3_g31760) | 3555708..3555932 | + | 225 | WP_109020912.1 | DUF433 domain-containing protein | - |
| DI077_RS16090 (LPTSP3_g31770) | 3555922..3556284 | + | 363 | WP_109020911.1 | DUF5615 family PIN-like protein | - |
| DI077_RS16095 (LPTSP3_g31780) | 3556320..3556478 | + | 159 | WP_167837173.1 | hypothetical protein | - |
| DI077_RS16100 (LPTSP3_g31810) | 3557007..3557219 | + | 213 | WP_109021317.1 | hypothetical protein | - |
| DI077_RS16105 (LPTSP3_g31820) | 3557252..3557530 | + | 279 | WP_109022133.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| DI077_RS16110 (LPTSP3_g31830) | 3557530..3557826 | + | 297 | WP_109021318.1 | HigA family addiction module antitoxin | Antitoxin |
| DI077_RS16115 (LPTSP3_g31840) | 3558004..3558645 | + | 642 | WP_109021319.1 | hypothetical protein | - |
| DI077_RS16120 (LPTSP3_g31860) | 3559156..3559362 | + | 207 | WP_100736135.1 | toxin-antitoxin system, antitoxin component | - |
| DI077_RS16125 (LPTSP3_g31870) | 3560080..3560310 | + | 231 | WP_109021320.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| DI077_RS16130 (LPTSP3_g31880) | 3560307..3560711 | + | 405 | WP_109021321.1 | type II toxin-antitoxin system VapC family toxin | - |
| DI077_RS16135 (LPTSP3_g31890) | 3560819..3561667 | + | 849 | WP_109021322.1 | GIY-YIG nuclease family protein | - |
| DI077_RS16140 (LPTSP3_g31900) | 3561678..3562046 | - | 369 | WP_217351565.1 | VOC family protein | - |
| DI077_RS16145 (LPTSP3_g31910) | 3562118..3562564 | + | 447 | WP_167837187.1 | MarR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3478404..3562564 | 84160 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10600.19 Da Isoelectric Point: 10.0038
>T39917 WP_109022133.1 NZ_AP025028:3557252-3557530 [Leptospira kobayashii]
VIKSFLHKGLEDFFNTGSKKGIRPDHSSKLARILDRLDASLKPEDMDLPGYKLHPLKGDKKKRWSVSVNGNWRVTFLFVG
KDAILVDYEDYH
VIKSFLHKGLEDFFNTGSKKGIRPDHSSKLARILDRLDASLKPEDMDLPGYKLHPLKGDKKKRWSVSVNGNWRVTFLFVG
KDAILVDYEDYH
Download Length: 279 bp
>T39917 NZ_AP025028:3557252-3557530 [Leptospira kobayashii]
GTGATCAAATCATTTCTTCATAAAGGTTTAGAAGATTTTTTCAATACTGGTAGCAAAAAAGGAATAAGACCTGATCACTC
TAGTAAACTTGCAAGGATATTAGATAGGTTAGATGCCTCTTTAAAGCCTGAAGACATGGATTTACCAGGATACAAGCTTC
ATCCTTTAAAAGGTGATAAAAAAAAGCGATGGTCTGTTTCCGTAAATGGAAATTGGAGAGTTACTTTTCTATTTGTTGGT
AAAGATGCAATTTTAGTTGATTATGAGGATTACCATTAA
GTGATCAAATCATTTCTTCATAAAGGTTTAGAAGATTTTTTCAATACTGGTAGCAAAAAAGGAATAAGACCTGATCACTC
TAGTAAACTTGCAAGGATATTAGATAGGTTAGATGCCTCTTTAAAGCCTGAAGACATGGATTTACCAGGATACAAGCTTC
ATCCTTTAAAAGGTGATAAAAAAAAGCGATGGTCTGTTTCCGTAAATGGAAATTGGAGAGTTACTTTTCTATTTGTTGGT
AAAGATGCAATTTTAGTTGATTATGAGGATTACCATTAA
Antitoxin
Download Length: 99 a.a. Molecular weight: 10970.86 Da Isoelectric Point: 10.5310
>AT39917 WP_109021318.1 NZ_AP025028:3557530-3557826 [Leptospira kobayashii]
MKNTKTRKPTHPGEVLLQDVLKPLNLPISEAAKSLGVSRKTLSEIVNQKAGITPNMAVRIAYATNTSAESWIRMQGKYDL
WLAMQEKINHIEKFPIAV
MKNTKTRKPTHPGEVLLQDVLKPLNLPISEAAKSLGVSRKTLSEIVNQKAGITPNMAVRIAYATNTSAESWIRMQGKYDL
WLAMQEKINHIEKFPIAV
Download Length: 297 bp
>AT39917 NZ_AP025028:3557530-3557826 [Leptospira kobayashii]
ATGAAAAACACTAAAACACGAAAGCCTACCCATCCGGGAGAAGTTTTACTCCAAGATGTCTTAAAACCTTTAAATTTACC
TATTTCTGAAGCTGCGAAAAGTTTAGGTGTCTCAAGAAAAACTCTTTCTGAAATTGTGAATCAAAAAGCTGGGATTACTC
CAAATATGGCTGTTAGAATCGCATATGCTACAAATACATCTGCTGAAAGCTGGATTCGAATGCAAGGAAAGTATGATCTT
TGGTTAGCTATGCAAGAAAAAATAAATCATATCGAAAAATTCCCTATCGCTGTTTAA
ATGAAAAACACTAAAACACGAAAGCCTACCCATCCGGGAGAAGTTTTACTCCAAGATGTCTTAAAACCTTTAAATTTACC
TATTTCTGAAGCTGCGAAAAGTTTAGGTGTCTCAAGAAAAACTCTTTCTGAAATTGTGAATCAAAAAGCTGGGATTACTC
CAAATATGGCTGTTAGAATCGCATATGCTACAAATACATCTGCTGAAAGCTGGATTCGAATGCAAGGAAAGTATGATCTT
TGGTTAGCTATGCAAGAAAAAATAAATCATATCGAAAAATTCCCTATCGCTGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|