Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3508634..3509208 Replicon chromosome
Accession NZ_AP025028
Organism Leptospira kobayashii strain E30

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DI077_RS15815 Protein ID WP_109020907.1
Coordinates 3508634..3508912 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DI077_RS15820 Protein ID WP_109020906.1
Coordinates 3508912..3509208 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DI077_RS15785 (LPTSP3_g31150) 3504387..3504611 + 225 WP_109020912.1 DUF433 domain-containing protein -
DI077_RS15790 (LPTSP3_g31160) 3504601..3504963 + 363 WP_109020911.1 DUF5615 family PIN-like protein -
DI077_RS15795 (LPTSP3_g31170) 3504999..3505157 + 159 WP_167837173.1 hypothetical protein -
DI077_RS15800 (LPTSP3_g31180) 3505400..3506398 + 999 WP_109020910.1 hypothetical protein -
DI077_RS15805 (LPTSP3_g31190) 3507155..3507847 + 693 WP_167837172.1 pentapeptide repeat-containing protein -
DI077_RS15810 (LPTSP3_g31200) 3508086..3508601 + 516 WP_109020908.1 hypothetical protein -
DI077_RS15815 (LPTSP3_g31210) 3508634..3508912 + 279 WP_109020907.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DI077_RS15820 (LPTSP3_g31220) 3508912..3509208 + 297 WP_109020906.1 HigA family addiction module antitoxin Antitoxin
DI077_RS15825 (LPTSP3_g31230) 3509502..3509879 + 378 WP_109020905.1 type II toxin-antitoxin system RelE/ParE family toxin -
DI077_RS15830 (LPTSP3_g31240) 3509845..3510162 + 318 WP_109020904.1 helix-turn-helix transcriptional regulator -
DI077_RS15835 (LPTSP3_g31250) 3510332..3511528 + 1197 WP_109020903.1 antiviral reverse transcriptase Drt3a -
DI077_RS15840 (LPTSP3_g31260) 3511521..3513404 + 1884 WP_109020902.1 antiviral reverse transcriptase Drt3b -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3478404..3562564 84160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10601.13 Da        Isoelectric Point: 9.4462

>T39916 WP_109020907.1 NZ_AP025028:3508634-3508912 [Leptospira kobayashii]
VIKSFLHKGLEDFFNTGSKKGIRPDHSSKLARILDRLDASLKPEDMDLPGYKLHPLKGDKKKRWSVSVNGNWRVTFLFVG
EDAILVDYEDYH

Download         Length: 279 bp

>T39916 NZ_AP025028:3508634-3508912 [Leptospira kobayashii]
GTGATTAAATCATTTCTTCATAAAGGCCTCGAGGATTTTTTCAATACTGGTAGCAAAAAAGGAATAAGACCTGATCACTC
TAGTAAACTTGCAAGGATATTAGATAGGTTAGATGCTTCCTTAAAGCCTGAAGACATGGATTTACCAGGATACAAGCTTC
ATCCTTTAAAAGGTGATAAGAAAAAGCGATGGTCTGTTTCGGTAAACGGAAATTGGAGAGTTACTTTTCTATTTGTTGGT
GAAGATGCAATTTTAGTAGATTATGAGGATTACCATTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10971.84 Da        Isoelectric Point: 10.3633

>AT39916 WP_109020906.1 NZ_AP025028:3508912-3509208 [Leptospira kobayashii]
MKNTKTRKPTHPGEVLLEDVLKPLNLPISEAAKSLGVSRKTLSEIVNQKAGITPNMAVRIAYATNTSAESWIRMQGKYDL
WLAMQEKINHIEKFPIAV

Download         Length: 297 bp

>AT39916 NZ_AP025028:3508912-3509208 [Leptospira kobayashii]
ATGAAAAACACTAAAACACGAAAGCCTACCCATCCGGGAGAAGTTTTACTCGAAGATGTCTTAAAACCTTTAAATTTACC
TATTTCTGAAGCTGCAAAAAGTTTAGGTGTCTCAAGAAAGACTCTTTCTGAAATTGTGAATCAAAAAGCTGGGATTACTC
CAAATATGGCTGTTAGAATCGCATATGCTACAAATACATCTGCTGAAAGTTGGATTCGAATGCAAGGAAAGTATGATCTT
TGGTTAGCTATGCAAGAAAAAATAAATCATATAGAAAAATTCCCTATCGCTGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References