39857

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2714684..2715927 Replicon chromosome
Accession NZ_AP024961
Organism Legionella pneumophila strain 80-045

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag LDN16_RS12060 Protein ID WP_027265541.1
Coordinates 2714989..2715927 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag LDN16_RS12055 Protein ID WP_027265542.1
Coordinates 2714684..2714992 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDN16_RS12030 (LEG80045_23420) 2710191..2710616 + 426 WP_027265547.1 hypothetical protein -
LDN16_RS12035 (LEG80045_23430) 2710879..2711244 - 366 WP_027265546.1 TraK family protein -
LDN16_RS12040 (LEG80045_23440) 2711587..2713353 - 1767 WP_027265545.1 DUF927 domain-containing protein -
LDN16_RS12045 (LEG80045_23450) 2713433..2713687 - 255 WP_027265544.1 helix-turn-helix domain-containing protein -
LDN16_RS12050 (LEG80045_23460) 2714460..2714687 + 228 WP_027265543.1 helix-turn-helix transcriptional regulator -
LDN16_RS12055 (LEG80045_23470) 2714684..2714992 + 309 WP_027265542.1 HipA N-terminal domain-containing protein Antitoxin
LDN16_RS12060 (LEG80045_23480) 2714989..2715927 + 939 WP_027265541.1 lpg2370 family Dot/Icm T4SS effector Toxin
LDN16_RS12065 (LEG80045_23490) 2716200..2716733 + 534 WP_027265540.1 hypothetical protein -
LDN16_RS12070 (LEG80045_23500) 2716730..2717662 + 933 WP_027265539.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LDN16_RS12075 (LEG80045_23510) 2717714..2718691 - 978 WP_027265538.1 metallophosphoesterase -
LDN16_RS12080 (LEG80045_23520) 2718721..2719734 - 1014 WP_027265537.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LDN16_RS12085 (LEG80045_23530) 2719727..2720332 - 606 WP_050598115.1 DUF6088 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(4-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36008.88 Da        Isoelectric Point: 9.2986

>T39857 WP_027265541.1 NZ_AP024961:2714989-2715927 [Legionella pneumophila]
MKHCPITYEKISVQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIQQFCTFPKIEFVKLFKLTLFNFLIGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGVSFLSQPMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

>T39857 NZ_AP024961:2714989-2715927 [Legionella pneumophila]
ATGAAACACTGTCCTATTACTTATGAAAAGATAAGTGTTCAAGAAAACTATTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAATCTTAGCCCATTAGATTTAAGTGCTGATGAGCAGCGACAGGAAGCAATTGCTCGTGTAGGAAAGATGT
CTATTCAAGGCGTTCAAAAGAAACTAAGTGCCAAACTAAAGATTAAAGAGGGATGTTTTGAAATCGTTGATCAATATGGT
CAGTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCTGAAAATGAAGCCATTACTATGACCCTTGCAAAAAC
TATAGGCCTCGAAGTTCCGGTTCATGGTTTGGTTTATTCTAAAGACAACAGTTTGACCTACTTCATTAAACGCTTTGATA
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGC
TCTATGGAAAAAGTAATTGCAGTCATACAGCAGTTTTGTACATTCCCAAAAATTGAATTCGTGAAATTATTTAAGCTGAC
GTTGTTTAACTTTCTGATTGGCAATGAAGATATGCATCTAAAAAATTTTTCCCTGATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTACGATTTACTTAACTCAACCATCGCTCAAAAAAATACCAAAGAAGAACTGGCTTTACCTCTAAAAGGA
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCATTGAAAAATTAGGATTAAACCAGAACGTCATCGA
TGGGATCGTACAAGAGTTCCATCAGGTAATACCAAAATGGCAAGAGCTGATTGGTGTCAGTTTTTTATCTCAACCGATGC
AGGAAAAATATCTCGAATTGCTAGAGCAACGATGCAAGCGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11527.33 Da        Isoelectric Point: 4.4805

>AT39857 WP_027265542.1 NZ_AP024961:2714684-2714992 [Legionella pneumophila]
MRKACVSVDGIKAGTLEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYEFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT39857 NZ_AP024961:2714684-2714992 [Legionella pneumophila]
ATGAGAAAAGCATGCGTATCAGTGGATGGCATTAAGGCTGGAACACTAGAAGAATTACAAGGTGGAACCTATCAATTTAC
CTACTTTGAGGATTATCACGGCGCACCTGTTTCACTCACTATGCCGTTGAAAAATAAGGTCTATGAATTTGACGTATTTC
CACCCTTTTTTGAAGGATTACTCCCTGAAGGCATTATGCTTGAAGCATTATTACGCAAATATAAAATCGATAAAAATGAT
TATTTTGGCCAATTGATACTAGTTGGCCAAGATGTCGTAGGTGCAGTGACTATTGAGGAATTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References