Detailed information of TA system TA039797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 1686873..1687506
• Replicon: chromosome
• Accession: NZ_AP024885
• Organism: Vibrio neonatus strain JCM 21521

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3CLA8
• Locus tag: OCU38_RS07770
• Protein ID: WP_021712689.1
• Coordinates: 1686873..1687205 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: OCU38_RS07775
• Protein ID: WP_261822637.1
• Coordinates: 1687192..1687506 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU38_RS07750	1682049..1683233	-	1185	WP_261824258.1	8-amino-7-oxononanoate synthase	-
OCU38_RS07755	1683220..1684272	-	1053	WP_261822634.1	biotin synthase BioB	-
OCU38_RS07760	1684394..1685674	+	1281	WP_261822635.1	adenosylmethionine--8-amino-7-oxononanoate transaminase	-
OCU38_RS07765	1686120..1686413	+	294	WP_261822636.1	hypothetical protein	-
OCU38_RS07770	1686873..1687205	+	333	WP_021712689.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCU38_RS07775	1687192..1687506	+	315	WP_261822637.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
OCU38_RS07780	1687577..1688884	-	1308	WP_023403596.1	serine--tRNA ligase	-
OCU38_RS07785	1688970..1690316	-	1347	WP_261822638.1	replication-associated recombination protein A	-
OCU38_RS07790	1690326..1690928	-	603	WP_023403594.1	outer membrane lipoprotein chaperone LolA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-92)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12936.78 Da
• Isoelectric Point: 10.0960

>T39797 WP_021712689.1 NZ_AP024885:1686873-1687205 [Vibrio neonatus]
MKSIFVESTIFEKYRNEYLSDDEFRLFQSELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKAFMEAWRNEQS

Nucleotide

• Length: 333 bp

>T39797 NZ_AP024885:1686873-1687205 [Vibrio neonatus]
ATGAAAAGTATATTTGTCGAATCAACCATATTTGAAAAGTACCGTAATGAATATCTCAGCGATGATGAGTTTAGGCTTTT
TCAATCTGAGTTAATGTCTAACCCGAAACAAGGTGACGTAATTCAAGGTACAGGTGGTTTGCGGAAAATTAGAGTTGCAA
GTAAAGGTAAAGGCAAGCGTGGCGGCTCTCGTGTTATCTATTATTTCCTCGACGAAAAGCGTCGATTCTACTTGCTGACG
ATTTATGGCAAGAATGAAATGTCTGATTTAACCGCAGACCAGAAGAAACAATTGAAAGCTTTTATGGAGGCGTGGCGTAA
TGAGCAGTCGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11787.30 Da
• Isoelectric Point: 5.6359

>AT39797 WP_261822637.1 NZ_AP024885:1687192-1687506 [Vibrio neonatus]
MSSRDLFTELSSALIEAKEHSEGKLTLKTYQVNDISELDISPNEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAITLLKLVQRHPETLSYIAEL

Nucleotide

• Length: 315 bp

>AT39797 NZ_AP024885:1687192-1687506 [Vibrio neonatus]
ATGAGCAGTCGTGATCTGTTTACAGAGTTAAGTTCAGCTCTGATTGAGGCTAAAGAACATTCTGAGGGTAAGTTAACCCT
TAAAACTTACCAAGTTAACGATATCAGTGAGTTAGATATTTCACCTAATGAGATCGTGAGTATTCGCGAACAATTTAATA
TGTCTCGTGGTGTGTTTGCTCGTTTACTGCATACGTCATCTCGTACATTAGAAAATTGGGAACAAGGGCGTAGCGCACCA
AATGGACAAGCGATAACCCTTCTAAAATTGGTTCAGCGTCATCCAGAAACTCTGTCATACATAGCTGAGCTATAA

Structures

Toxin

• AlphaFold DB: U3CLA8